MODELLING



     

Wound Dressing Mechanism
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Wound Dressing Layer Design
Rapid and proper healing is important in the treatment of wounds such as severe burns, trauma, diabetic,decubitus and venous stasis ulcers, and similar tissue damages. In cases of severe and large amounts of skin loss, or in the presence of difficult and non-healing wounds, immediate coverage of the wound surface with a dressing is needed. The dressing achieves the functions of the natural skin by protecting the area from the loss of fluid and proteins, preventing infection through bacterial invasion, and subsequent tissue damage. In some cases, it improves healing by providing a support for the proliferating cells.

<img src="http://2009.igem.org/wiki/images/0/06/Gltn.jpg" style="width:30%; height:30%; border:0px solid #aaa; margin:-10px 5px 10px 15px;"> <img src="http://2009.igem.org/wiki/images/1/17/Mrb.jpg" style="width:15%; height:15%; border:0px solid #aaa; margin:-10px 5px 10px 15px;"> <img src="http://2009.igem.org/wiki/images/a/a1/Clgn.jpg" style="width:30%; height:30%; border:0px solid #aaa; margin:-10px 5px 10px 0px;">

Biomaterials Modelling
Characterization of the rhEGF-collagen sponges

[1]Determination of the degree of crosslinking

The crosslinking degree could then be obtained from the differences between the absorbance values before and after the crosslinking. The equation is as follows:

http://2009.igem.org/wiki/images/9/9b/Formul1.jpg

where s is the sample and ncl is non-crosslinked.

[2]Water-binding capacity

The water uptake of the collagen sponges was calculated using the following equation:

http://2009.igem.org/wiki/images/a/a3/Formul2.jpg

where Wd is the weight of the dry sponge and Ws is the weight of the swollen sponge.

[3]Release kinetics

To determine the possible release mechanism, drug release from collagen sponges was fitted to the following power model:

http://2009.igem.org/wiki/images/6/64/Formul3.jpg

where Mt/M is the fractional drug release percentage at time t, and k is a constant related to the properties of the drug delivery system and n is the diffusional exponent which characterizes the drug transport mechanism.

<div class="main_item"> Recombinant hEGF released from collagen sponges

<div class="main_item"> The rhEGF release patterns from collagen sponges

Conclusion
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