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Team:NTU-Singapore
From 2009.igem.org
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Our system, '''p'''Laq''U''<span class="sup">e</span> Out<span class="serif bold">''!''</span>, ideally in a macrophage chassis, when introduced into the bloodstream, will be activated by a symptom that is typical of plaque buildup. Upon activation, our system will release a cholesterol degrading enzyme, a novel reporter protein and a vasodilator. | Our system, '''p'''Laq''U''<span class="sup">e</span> Out<span class="serif bold">''!''</span>, ideally in a macrophage chassis, when introduced into the bloodstream, will be activated by a symptom that is typical of plaque buildup. Upon activation, our system will release a cholesterol degrading enzyme, a novel reporter protein and a vasodilator. | ||
| - | # The cholesterol degrading enzyme | + | |
| - | # The reporter protein | + | # The sense construct triggers the system in response to falling nitric oxide concentrations. |
| - | # Finally the vasodilator will simultaneously dilate the blood vessels for better flow, as well as switch off the extended activity of our system. | + | # The cholesterol degrading enzyme breaks down the plaque. |
| + | # The reporter protein, with its unique fluorescent property, allows the plaque site to be visualized ''in vivo''. | ||
| + | # Finally, the vasodilator will simultaneously dilate the blood vessels for better flow, as well as switch off the extended activity of our system. | ||
For now, E. coli is used as a model organism to test our system. | For now, E. coli is used as a model organism to test our system. | ||
| - | + | <div class="grid_7 alpha"> | |
=== About the team === | === About the team === | ||
This marks the second year NTU-Singapore is taking part in this competition. The team consists of 8 undergraduates, guided by 7 instructors and 3 advisors. We are really looking forward to pitting our minds against top minds in universities worldwide, and eventually meeting everyone at the iGEM Jamboree. Good luck everyone! | This marks the second year NTU-Singapore is taking part in this competition. The team consists of 8 undergraduates, guided by 7 instructors and 3 advisors. We are really looking forward to pitting our minds against top minds in universities worldwide, and eventually meeting everyone at the iGEM Jamboree. Good luck everyone! | ||
| + | </div> | ||
| - | + | <div class="grid_4 omega"> | |
| + | === Accomplishments! === | ||
| + | </div><br class="clear' /> | ||
<div class="grid_8 alpha"> | <div class="grid_8 alpha"> | ||
Revision as of 04:25, 16 October 2009
Welcome to NTU@iGEM '09
Blah
This is ADM!
Hello iGEM.
Welcome to the official Nanyang Technological University project wiki for iGEM '09.
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About our project
Atherosclerosis is a growing healthcare concern, affecting millions of people worldwide every year. Conventional treatments are painful and invasive, yet they merely treat symptoms, but do not prevent or cure. The NTU iGEM ’09 team is proud to announce that we are working on a proposed alternative treatment for this disease.
Our system, pLaqUe Out!, ideally in a macrophage chassis, when introduced into the bloodstream, will be activated by a symptom that is typical of plaque buildup. Upon activation, our system will release a cholesterol degrading enzyme, a novel reporter protein and a vasodilator.
- The sense construct triggers the system in response to falling nitric oxide concentrations.
- The cholesterol degrading enzyme breaks down the plaque.
- The reporter protein, with its unique fluorescent property, allows the plaque site to be visualized in vivo.
- Finally, the vasodilator will simultaneously dilate the blood vessels for better flow, as well as switch off the extended activity of our system.
For now, E. coli is used as a model organism to test our system.
About the team
This marks the second year NTU-Singapore is taking part in this competition. The team consists of 8 undergraduates, guided by 7 instructors and 3 advisors. We are really looking forward to pitting our minds against top minds in universities worldwide, and eventually meeting everyone at the iGEM Jamboree. Good luck everyone!
Accomplishments!
Our top sponsors
We would like to sincerely thank our Gold sponsors, Genentech Singapore and Johnson & Johnson Singapore for their invaluable contribution to the team!
Visitor's info
