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Team:TUDelft/Brainstorm
From 2009.igem.org
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Revision as of 11:56, 27 April 2009
Brainstorm area
Interesting Links
- [http://openwetware.org/wiki/IGEM:Idea_exchange iGEM Idea Exchange]
- [http://openwetware.org/wiki/Tk:wanted_parts TK: Wanted Parts]
- [http://openwetware.org/wiki/IGEM:Projects_categorized iGEM:Projects categorized]
- [http://openwetware.org/wiki/Synthetic_Biology:Vectors/Wishlist Synthetic_Biology:Vectors/Wishlist]
Brainstorm ideas
Impulse Signal
- one suggestion (by Federico C.) from the idea exchange was to create a self-destructing plasmid, which would express once and than destroy itself with a restriction endonuclease in its code.
Water Soluble Vitamin Production
- produce Vitamins B and C.
Stop Quorum Signalling -> Quenching AHL
- aiiA enzyme [http://www.msk.or.kr/jsp/view_old_journalD.jsp?paperSeq=2133] already has a biobrick [http://partsregistry.org/Part:BBa_C0060 Part:BBa_C0060] but it is not secreted.
- halogenated furanones [http://mic.sgmjournals.org/cgi/content/full/151/11/3589?view=long&pmid=16272381] [http://mic.sgmjournals.org/cgi/content/full/148/4/1119?view=long&pmid=11932456] decrease binding activity of LuxR.
- [http://www.molbio.princeton.edu/index.php?option=content&task=view&id=27 Bonnie Bassler]'s research, inhibit quorum signaling with molecules structurally similar to AHL. Her recent [http://www.ted.com/index.php/talks/bonnie_bassler_on_how_bacteria_communicate.html TED Talk].
Biological Isotope Separation
- is it even possible?
- according to this [http://jol.liljenzin.se/BOOK.HTM book] in section 2.6.5. [http://jol.liljenzin.se/KAPITEL/CH02NY3.PDF], both chlorella algae and E.coli have isotope enrichment properties (hydrogen, deuterium). no references given.
- possible applications: remove radioactive isotopes from body (cancer treatments), separate heavy water from ocean water, remove carbon 14 and potassium 40 from body/food.
- another paper is Bioseparation of Lithium Isotopes by Using Microorganisms, Sakaguchi, Takashi | Tomita, Osamu, Resource and Environmental Biotechnology [Resour. Environ. Biotechnol.]. Vol. 3, no. 2-3, pp. 173-182. 2000. havent found a copy online.
Saltwater Purification
- + heavy metal extraction
- diatoms
- Dead Sea organisms
Xylitol production
- already attempted, see [http://openwetware.org/images/0/03/6-bolaji.pdf]
Melatonin Compensation
- compensate the reduction in melatonin levels caused by the invention of electrical lights
- has been linked to lots of medical problems, see review paper [http://www.psy.ohio-state.edu/nelson/documents/JPinealRes2007.pdf The dark side of light at night: physiological, epidemiological, and ecological consequences]
- would need to implement melatonin detection, synthesis, and a clock
New Antibiotic Cassettes
- Biobricks exist for Ampicillin, Kanamycin, Chloramphenicol, and Tetracycline.
- New biobricks needed (see TK:Wishlist), integrate into larger project?
- Cationic peptides, Rhodostreptomycins [http://mit.edu/biology/sinskey/www/Kurosawa2008.pdf]
Paper Based Microfluidics with bacteria
- Improve the processing outlined in [http://www.rsc.org/delivery/_ArticleLinking/ArticleLinking.cfm?JournalCode=LC&Year=2008&ManuscriptID=b811135a&Iss=12 FLASH: A rapid method for prototyping paper-based microfluidic devices], see papers from Whitesides group at Harvard.
- use light sensor and output hydrophobic/hydrophilic chemicals that can coat the cellulose in the paper placed on an agar plate
Close proximity phage expression
- once a cell is close enough to a target, produce phages and explode
Anti-Venom System
- inject bacteria after being bitten
- sense which venom and produce proper anti-venom
Birth Control Yoghurt
- attacks sperm
- animal use
Buoyant Bacteria
- for metal extraction from old mines or ocean
Excrement Degradation Bacteria
- dog excrements degrades quickly
- can be used in as excrement degrader instead of waste tank in portable toilets or [http://en.wikipedia.org/wiki/Deodorize deodorizing] excrements in chemical toilets
Additional Processing of Excretion for Energy
- Zero Growth -> convert everything to product
Targeted Delivery
- use THC for medical benefits without any psychoactive effects
microRNA and P53
- inhibit miRNA to increase activity of tumor-suppressor gene p53
- needs targeted delivery system
Synchronization -> Flashing Colony
- synchronized flashing
- covalent modification
Sensor Reporter Spatially Displaced
Kalman Filter
- integrate into larger project
Stopping a Cytokine storm
- something which could break the feedback loop in a cytokine storm
