Team:LCG-UNAM-Mexico:BSD

From 2009.igem.org

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==Content==
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*Wild Type Distribution<br>
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*[[Team:LCG-UNAM-Mexico:BSD#The Burst Size Distribution]]<br>
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*Simulated BSD
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*[[Team:LCG-UNAM-Mexico:BSD#Simulated BSD]]<br>
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*BSD using the Defense System
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*[[Team:LCG-UNAM-Mexico:BSD#BSD using the Defense System<br>
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==Wild Type Distribution==
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==The Burst Size Distribution==
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In 1939 Ellis and Delbrück obtained values which indicated an exceedingly wide variation of the burst sizes for different bacteriophages. In 1945 Delbrück published the first Burst-Size distribution using an improved technique for bacteriophage T1.
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The reported values for the burst size of T7 are in the range x-y, this values are used in many population models for bacteriophage infection [][][].<br><br>
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It is important to have a reliable simulation of the intracellular dynamics in order to generate values for the burst-size. Creating a Burst-Size distribution is one of the most important things of our work since it will be the link between the intracellular scale and the population scale simulations.
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The BSD is by no means the only distributions generated by our [Team:LCG-UNAM-Mexico:Molecular model | intracellular simulations], distributions for each species in the model are generated indeed.
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==Simulated BSD==
==Simulated BSD==
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Without [[Team:LCG-UNAM-Mexico:Project#defense | defence system]] our simulated BSD has mean 176 and standard deviation 102. This distribution was created running 1000 simulations of the intracellular model.<br>
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We see that experimentally measured values fall within this distribution. The large variance seen by Delbrück and the dispersion in experimental values is congruent with our results (table 1).
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==BSD using the Defense System==
==BSD using the Defense System==
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Revision as of 04:18, 20 October 2009


The Burst-Size Distribution


Content



The Burst Size Distribution


In 1939 Ellis and Delbrück obtained values which indicated an exceedingly wide variation of the burst sizes for different bacteriophages. In 1945 Delbrück published the first Burst-Size distribution using an improved technique for bacteriophage T1.

The reported values for the burst size of T7 are in the range x-y, this values are used in many population models for bacteriophage infection [][][].

It is important to have a reliable simulation of the intracellular dynamics in order to generate values for the burst-size. Creating a Burst-Size distribution is one of the most important things of our work since it will be the link between the intracellular scale and the population scale simulations. The BSD is by no means the only distributions generated by our [Team:LCG-UNAM-Mexico:Molecular model | intracellular simulations], distributions for each species in the model are generated indeed.





Simulated BSD



Without defence system our simulated BSD has mean 176 and standard deviation 102. This distribution was created running 1000 simulations of the intracellular model.
We see that experimentally measured values fall within this distribution. The large variance seen by Delbrück and the dispersion in experimental values is congruent with our results (table 1).





BSD using the Defense System




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