Revision as of 20:46, 21 October 2009 by Daadracula
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Safe E. coli
Q. How can you sure your E. coli is really safe?
A. Reference to previous works from other iGEM teams, for example, the BactoBlood project of UC Berkeley, to see their strategies for making E. coli safe.
Q. What are the binding affinities for each receptor?
A. Even our viro terminator can not bind the virus well, it can also build up the local concentration of virus, and then have the ability to attract microphage.
Q. What does the genome of HIV consist of?
A. The full HIV genome is encoded on one long strand of RNA. (In a free virus particle, there are actually two separate strands of RNA, but they're exactly the same!) This is the form it has when it is a free virus particle. When the virus is integrated into the host's DNA genome (as a provirus) then its information too is encoded in DNA. (from www.mcld.co.uk/hiv/)
Q. How dose the HIV enters a human cell?
A. HIV enter macrophage and CD4+ T cell of human cell by the adsorption of their glycoprtein on the traget receptor. Afetr adsorption finished, virus envelope fusion with membrane of target cell, then genome of HIV can entry the target cell.
Integrin (various viruses)
Sialic acid (Influenza)
Antibodies (Specific chosen viruses)
Host cell and signal transduction
in vivo questions
After clinical tests
Q. How can we control the number of E. coli in our blood?
A. We will make the E. coli not be able to replicate.
Q. What is the dosage required for say a person with flu?
A. This is a question for sometime between in vivo testing and clinical trials.