Team:Valencia/Simulations

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== '''Try Your Own Simulations''' ==
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<div align="justify" style="position:relative; margin-top:-250px; margin-left:195px; width:700px; color:black; font-size:10pt; font-family:Verdana">
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<span style="color:black; align:justify; font-size:11pt; font-family: Verdana">Here you have a "demo" where you can see our system's response with differents parameters (a further explanation is available below):
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== '''Simulations''' ==
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<br>
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Here you have a "demo" where you can see our system's response with differents parameters (a further explanation is available below):
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<html><embed src="https://static.igem.org/mediawiki/2009/b/bd/Carrousel_modelling_valencia.swf" type="application/x-shockwave-flash" width="750" height="550"></embed></html></div>
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<br>Click on the following image to download the application and try your own simulations!<br><br><br>
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    <embed src="https://static.igem.org/mediawiki/2009/b/bd/Carrousel_modelling_valencia.swf" type="application/x-shockwave-flash" width="800" height="600"></embed>
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<span style="color:black; align:justify; font-size:11pt; font-family: Verdana">Click on the following image to download the application and try your own simulations!
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<html><a href="https://static.igem.org/mediawiki/2009/0/05/Matlab_modelling_interface.zip" target="_blank"> <img src="https://static.igem.org/mediawiki/2009/4/4f/InterfaceGuide.gif" width="630" height="471"></a></html>
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<html><a href="https://static.igem.org/mediawiki/2009/0/05/Matlab_modelling_interface.zip" target="_blank"> <img src="https://static.igem.org/mediawiki/2009/4/4f/InterfaceGuide.gif" width="800" height="600"></a></html></div>
 
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== '''Our Simulations''' ==
== '''Our Simulations''' ==
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<span style="color:black; align:justify; font-size:11pt; font-family: Verdana">
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Before simulating how intracellular calcium concentration changes in time, we have approximated the '''excitatory post-synaptic potential''' function (our "input" in neurons) as follows:  
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<span style="color:black; align:justify; font-size:11pt; font-family:Verdana">Before simulating how intracellular calcium concentration changes in time, we have approximated the '''excitatory post-synaptic potential''' function (our "input" in neurons) as follows:  
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[[Image:Voltage_neurons.jpg|480px|center]]
[[Image:Voltage_neurons.jpg|480px|center]]
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<span style="color:black; align:justify; font-size:11pt; font-family:Verdana">Then, taking into account all the factors listed in [https://2009.igem.org/Team:Valencia/OurModel '''Our Model'''] (Calcium current through VDCCs, Calcium Buffering and Calcium pumps), the result of simulating '''free intracellular calcium concentration''' after the electrical stimulation in '''neurons''' is this:  
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Then, taking into account all the factors listed in [https://2009.igem.org/Team:Valencia/OurModel '''Our Model'''] (Calcium current through VDCCs, Calcium Buffering and Calcium pumps), the result of simulating '''free intracellular calcium concentration''' after the electrical stimulation in '''neurons''' is this:  
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<span style="color:black; align:justify; font-size:11pt; font-family:Verdana">On the other hand, '''cardiomyocytes''' have a '''different response''' to an electrical stimulus, as now our “input” '''voltage function''' is different: unlike neurons, its plasma membrane is held at a high voltage for a few hundred milliseconds.
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On the other hand, '''cardiomyocytes''' have a '''different response''' to an electrical stimulus, as now our “input” '''voltage function''' is different: unlike neurons, its plasma membrane is held at a high voltage for a few hundred milliseconds.
[[Image:Voltage_muscle.jpg|540px|center]]
[[Image:Voltage_muscle.jpg|540px|center]]
[[Image:Calcium_muscle.jpg|560px|center]]
[[Image:Calcium_muscle.jpg|560px|center]]
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The numeric values for the '''simulation parameters''' are shown in the following table:
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<span style="color:black; align:justify; font-size:11pt; font-family:Verdana">The numeric values for the '''simulation parameters''' are shown in the following table:
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[[Image:Tabla.jpg|center|300px]]
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[[Image:Tabla.jpg|center]]
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Latest revision as of 00:36, 22 October 2009


Simulations


Here you have a "demo" where you can see our system's response with differents parameters (a further explanation is available below):






Click on the following image to download the application and try your own simulations!



Our Simulations

Before simulating how intracellular calcium concentration changes in time, we have approximated the excitatory post-synaptic potential function (our "input" in neurons) as follows:

Voltage neurons.jpg

Then, taking into account all the factors listed in Our Model (Calcium current through VDCCs, Calcium Buffering and Calcium pumps), the result of simulating free intracellular calcium concentration after the electrical stimulation in neurons is this:


Calcium neurons.jpg


On the other hand, cardiomyocytes have a different response to an electrical stimulus, as now our “input” voltage function is different: unlike neurons, its plasma membrane is held at a high voltage for a few hundred milliseconds.

Voltage muscle.jpg
Calcium muscle.jpg

The numeric values for the simulation parameters are shown in the following table:

Tabla.jpg