Wound Dressing
From 2009.igem.org
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<h2>Coagulation</h2> | <h2>Coagulation</h2> | ||
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- | <p style="font-size:110%; color:#576f91; font-family:georgia,serif;"><br>'''Figure:Hand abrasion, 30 minutes after injury.''' | + | <p style="font-size:110%; color:#576f91; font-family:georgia,serif;"><br> '''Figure:Hand abrasion, 30 minutes after injury.''' |
- | <br>Any injury results in disruption of blood vessels leading to haemorrhage which is controlled by clot formation which contains fibrin mesh with aggregated platelets embedded in it. Fibrin is the end product of coagulation pathway and besides causing heamostasis it is also the primary component of the provisional tissue matrix seen in the early phases of wound healing. It provides a scaffold for the migration of inflammatory and mesenchymal cells. | + | <br> Any injury results in disruption of blood vessels leading to haemorrhage which is controlled by clot formation which contains fibrin mesh with aggregated platelets embedded in it. Fibrin is the end product of coagulation pathway and besides causing heamostasis it is also the primary component of the provisional tissue matrix seen in the early phases of wound healing. It provides a scaffold for the migration of inflammatory and mesenchymal cells. |
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- | <p style="font-size:110%; color:#576f91; font-family:georgia,serif;"><br>'''Figure 2 : 2 days after injury.''' | + | <p style="font-size:110%; color:#576f91; font-family:georgia,serif;"><br> '''Figure 2 : 2 days after injury.''' |
- | <br>Tissue trauma stimulates the inflammatory response. Immediately after injury intense local vasoconstriction occurs, mediated by circulating catecholeamines and prostaglandins released by injured cells. This is followed by vasodilatation and increased capillary permeability resulting in local edema. This is mediated by histamine, kinins, prostaglandins, leukotrienes, and endothelial cell products. | + | <br> Tissue trauma stimulates the inflammatory response. Immediately after injury intense local vasoconstriction occurs, mediated by circulating catecholeamines and prostaglandins released by injured cells. This is followed by vasodilatation and increased capillary permeability resulting in local edema. This is mediated by histamine, kinins, prostaglandins, leukotrienes, and endothelial cell products. |
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- | Monocytes transform into macrophages as they migrate from capillaries into extra vascular space. Macrocytes phagocytose bacteria and tissue debris and secrete enzymes (collagenase and elastase) responsible for breaking down damaged matrix. They also cytokines, P.G.s, oxygren free radicals and other regulators of wound healing. | + | <br> Monocytes transform into macrophages as they migrate from capillaries into extra vascular space. Macrocytes phagocytose bacteria and tissue debris and secrete enzymes (collagenase and elastase) responsible for breaking down damaged matrix. They also cytokines, P.G.s, oxygren free radicals and other regulators of wound healing. |
Revision as of 09:31, 21 October 2009
Wound Healing Steps
Coagulation
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Inflammation
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