Wound Dressing
From 2009.igem.org
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- | <p style="font-size:110%; color:#576f91; font-family:georgia,serif;"><br> '''Figure 2 : | + | <p style="font-size:110%; color:#576f91; font-family:georgia,serif;"><br> '''Figure 2 : 17 days after injury.''' |
<br>Epithelialization alone is enough to provide total healing in partial thickness wounds. Incisional wounds are usually completely re-epithelized in 24-48 hrs. | <br>Epithelialization alone is enough to provide total healing in partial thickness wounds. Incisional wounds are usually completely re-epithelized in 24-48 hrs. | ||
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Unfortunately regenerated epithelium does not retain all the functional advantages of normal epithelium. These include fewer basal cells, abnormal interface between dermis and epidermis and thin epithelium in the mid portion of the re-epithelized wound. | Unfortunately regenerated epithelium does not retain all the functional advantages of normal epithelium. These include fewer basal cells, abnormal interface between dermis and epidermis and thin epithelium in the mid portion of the re-epithelized wound. | ||
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+ | <h2>Collagen sythesis</h2> | ||
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+ | <html><div align="center" style="padding-left: 66px; padding-top: 8px;"><img style="border: 0px solid ; width: 250px; height: 250px;" alt="w6" src="https://2009.igem.org/Image:800px-Hand_Abrasion_-_30_days_4_hours_43_minutes_after_injury.jpg"></a></div></html> | ||
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+ | <p style="font-size:110%; color:#576f91; font-family:georgia,serif;"><br> '''Figure 2 : 30 days after injury.''' | ||
+ | <br>Once the fibroblast has migrated into the wound, they switch there major function to protein synthesis. Collagen is the major component of the normal skin, granulation tissue and mature scar and is synthesized primarily by the fibroblasts. This activity starts by 3-5 days post injury and the rate of synthesis increases rapidly and continues at an accelerated rate for 2-4 weeks and starts declining after 4 weeks eventually becoming equal to rate of collagen destruction by collagenase. Collagen provides structural configuration, strength and matrix for cellular mobility in the wound. | ||
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+ | '''Matrix components-collagen fibre lysis and contraction''' | ||
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+ | <br>Replacement of extra-cellular matrix is a complex process as it contains components other than collagen including proteoglycans, fibronectin and elastin. | ||
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+ | Proteoglycans are synthesized primarily by fibroblasts and consists of protein core covalently linked to glycosaminoglycans including chondroitin sulphate, dermatan sulphate, heparin & heparin sulphate, keratan sulphate and hyaluronic acid. | ||
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+ | Fibronectin are mainly attachment proteins and important in various phases of wound healing. | ||
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+ | Elastin is not synthesized in response to injury and hence the absence of elasticity in scar tissue. | ||
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+ | '''Wound contraction''' | ||
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+ | <br>Starts 4-5 days after injury, and is represented by centripetal movement of wound edges towards the centre of the wound. The average rate of wound contraction is 0.6-0.75 mm/day. Myofibroblasts in the injured area are thought to be responsible for wound contraction. | ||
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Revision as of 09:38, 21 October 2009
Contents |
Wound Healing Steps
Coagulation
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Inflammation
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Epithelialization
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Collagen sythesis
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