Team:Brown

From 2009.igem.org

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     <td colspan="2"><a href="https://2009.igem.org/Team:Brown/Project"><img src="https://static.igem.org/mediawiki/2009/2/2a/Projectabstractbutton.gif" width="335" height="100"></td>
     <td colspan="2"><a href="https://2009.igem.org/Team:Brown/Project"><img src="https://static.igem.org/mediawiki/2009/2/2a/Projectabstractbutton.gif" width="335" height="100"></td>
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     <td colspan="3"><p><p><i>Learn more about Allergene: a synthetically engineered, self-regulating drug factory in the nose.</i> </td>
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     <td colspan="3">&nbsp<i>Learn more about Allergene: a synthetically engineered, self-regulating drug factory in the nose.</i> </td>
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     <td colspan="2"><a href="https://2009.igem.org/Team:Brown/Project_Histamine_Sensor"><img src="https://static.igem.org/mediawiki/2009/d/d0/Histaminesensorbutton.gif" width="335" height="100"></td>
     <td colspan="2"><a href="https://2009.igem.org/Team:Brown/Project_Histamine_Sensor"><img src="https://static.igem.org/mediawiki/2009/d/d0/Histaminesensorbutton.gif" width="335" height="100"></td>
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     <td colspan="3"><p><p><i>When an allergic response occurs, our system senses a change in histamine levels above threshold and initiates an intracellular cascade, signaling cells to respond appropriately to the increase in histamine concentration.</i> </td>
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     <td colspan="3">&nbsp<i>When an allergic response occurs, our system senses a change in histamine levels above threshold and initiates an intracellular cascade, signaling cells to respond appropriately to the increase in histamine concentration.</i> </td>
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     <td colspan="2"><a href="https://2009.igem.org/Team:Brown/Project_S.epidermidis"><img src="https://static.igem.org/mediawiki/2009/3/3c/S.epibutton.gif" alt="" width="335" height="100"></td>
     <td colspan="2"><a href="https://2009.igem.org/Team:Brown/Project_S.epidermidis"><img src="https://static.igem.org/mediawiki/2009/3/3c/S.epibutton.gif" alt="" width="335" height="100"></td>
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     <td colspan="3"><p><p><i>The chassis of choice  for production and secretion of the Histamine Binding Protein is Staphyloccocus Epidermidis, an organism endogenous to the human nasal flora. A quorum sensing mechanism was also incorporated to regulate cell density.</i>  </td>
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     <td colspan="3">&nbsp<i>The chassis of choice  for production and secretion of the Histamine Binding Protein is Staphyloccocus Epidermidis, an organism endogenous to the human nasal flora. A quorum sensing mechanism was also incorporated to regulate cell density.</i>  </td>
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     <td colspan="2"><a href="https://2009.igem.org/Team:Brown/Project_HBP"><img src="https://static.igem.org/mediawiki/2009/7/70/Hbpbutton.gif" alt="" width="335" height="100"></td>
     <td colspan="2"><a href="https://2009.igem.org/Team:Brown/Project_HBP"><img src="https://static.igem.org/mediawiki/2009/7/70/Hbpbutton.gif" alt="" width="335" height="100"></td>
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     <td colspan="3"><p><p><i>EV131 is a high-affinity histamine binding protein, that originates from the saliva of a female tick species.</i> </td>
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     <td colspan="3">&nbsp<i>EV131 is a high-affinity histamine binding protein, that originates from the saliva of a female tick species.</i> </td>
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     <td colspan="2"><a href="https://2009.igem.org/Team:Brown/Project_All_Together"><img src="https://static.igem.org/mediawiki/2009/1/12/Alltogetherbutton.gif" alt="All Together" width="335" height="100"></a></td>
     <td colspan="2"><a href="https://2009.igem.org/Team:Brown/Project_All_Together"><img src="https://static.igem.org/mediawiki/2009/1/12/Alltogetherbutton.gif" alt="All Together" width="335" height="100"></a></td>
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     <td colspan="3"><p><p><i>Description of the overall construct</i> </td>
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     <td colspan="3">&nbsp<i>Description of the overall construct</i> </td>
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Revision as of 01:14, 22 October 2009




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Every year, over fifty million people in the US suffer from allergic rhinitis, the most common type of allergy. Allergens such as pollen, dust, and dander result in nasal congestion, itching, burning, sneezing, and overall discomfort. Current treatments include over-the-counter antihistamines, however, side effects of these drugs include drowsiness, restlessness, and poor concentration. For patients suffering from chronic allergies and inflammation, there is a great need for an alternative strategy for combating allergic symptoms without causing significant side effects.


The 2009 Brown University iGEM team worked to treat allergic rhinitis by engineering Staphylococcus epidermidis, a microbe endogenous to the human nasal flora, to secrete a recombinant histamine-binding protein in response to the elevated histamine concentrations of an allergic response. The engineered strain of S. epidermidis will function as a self-regulating drug factory in the nose, providing relief, without any negative side effects.


&nbspLearn more about Allergene: a synthetically engineered, self-regulating drug factory in the nose.
&nbspWhen an allergic response occurs, our system senses a change in histamine levels above threshold and initiates an intracellular cascade, signaling cells to respond appropriately to the increase in histamine concentration.
&nbspThe chassis of choice for production and secretion of the Histamine Binding Protein is Staphyloccocus Epidermidis, an organism endogenous to the human nasal flora. A quorum sensing mechanism was also incorporated to regulate cell density.
&nbspEV131 is a high-affinity histamine binding protein, that originates from the saliva of a female tick species.
All Together &nbspDescription of the overall construct 


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