|
|
| (2 intermediate revisions not shown) |
| Line 1: |
Line 1: |
| - | <html xmlns="http://www.w3.org/1999/xhtml">
| |
| - | <head>
| |
| - | <meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1" />
| |
| - | <link href="http://igem2009hkust.fileave.com/wiki/template/12092009/style.css " rel="stylesheet" type="text/css" />
| |
| - | <title>Salt and Soap template</title>
| |
| - | </head>
| |
| | | | |
| - | <bodyxx>
| |
| - | <div id="containerxx">
| |
| - | <div id="headerxx">
| |
| - |
| |
| - | </div>
| |
| - | <div id="borderxx">
| |
| - | <div id="mainxx">
| |
| - | <div id="leftxx">
| |
| - | <div id="menuxx">
| |
| - | <ul>
| |
| - | <li><a href="https://2009.igem.org/Team:HKUST">Home</a></li>
| |
| - | <li><a href="https://2009.igem.org/Team:HKUST/Members">Our Team</a></li>
| |
| - | <li><a href="https://2009.igem.org/Team:HKUST/Project">Project description</a></li>
| |
| - | <li><a href="https://2009.igem.org/Team:HKUST/Background">Background</a></li>
| |
| - | <li><a href="https://2009.igem.org/Team:HKUST/Experiment">Experimental design</a></li>
| |
| - | <li><a href="https://2009.igem.org/Team:HKUST/Lab Notebook">Lab Notebook</a></li>
| |
| - | <li><a href="https://2009.igem.org/Team:HKUST/Result">Experimental result</a></li>
| |
| - | <li><a href="https://2009.igem.org/Team:HKUST/Parts">Parts Submitted </a></li>
| |
| - | <li><a href="https://2009.igem.org/Team:HKUST/Protocols">Protocol list</a></li>
| |
| - | <li><a href="https://2009.igem.org/Team:HKUST/Resourses">Other resources</a></li>
| |
| - | <li><a href="https://2009.igem.org/Team:HKUST/Future">Future plan</a></li>
| |
| - | </ul>
| |
| - | </div>
| |
| - | <div id="menubottom">
| |
| - | <ul>
| |
| - | <li><a href="https://2009.igem.org/Team:Gallery">Gallery</a></li>
| |
| - | <li><a href="https://2009.igem.org/Team:Consolidation">Consolidation</a></li>
| |
| - | <li><a href="https://2009.igem.org/Team:Acknowledgement">Acknowledgement</a></li>
| |
| - | </ul>
| |
| - | </div>
| |
| - | </div>
| |
| - | <div id="rightxx">
| |
| - | <div class="contentxx">
| |
| - | <h3>Welcome</h3>
| |
| - |
| |
| - | <p>GPCRs</p>
| |
| - | <p> G protein-coupled receptors (GPCRs) are main sensors of cells. They respond to ligands such as most hormones, neurotransmitters, light, odorants, taste substances, pheromones, and varieties of medicines. GPCRs comprise one of the largest protein superfamilies: it is estimated that there are 1050 and 160 GPCR genes in the genomes of Caenorhabditis elegans and Drosophila melanogaster, corresponding to 5.5% and 1% of their total genes, respectively . To identify the ligands may lead to discovery of novel hormones, neurotransmitters ect., and should contribute to the development of new medicines. In fact, GPCRs are known to target 30-60% of present medicines.</p>
| |
| - | <p>GPCRs are seven transmembrane proteins (Fig1). Stimulated by extracellular ligands, the receptors act through heterotrimeric G proteins to regulate intracellular effector proteins. The G proteins are composed of Gα-Gβ-and Gγ-subunits. In the inactive state, the Gα-subunit is bound to GDP and associated with the Gβ-and Gγ-dimer. Upon ligand binding, the receptor stimulates the release of GDP from Gα, allowing the binding of GTP. Gα-GTP is released from the Gβ-and Gγ-dimer, and the dissociated subunits regulate the activity of effector proteins such as adenylate cyclase, phospholipase C, mitogen-activated protein kinase (MAP kinase) cascades and ion channels.
| |
| - | </p>
| |
| - |
| |
| - |
| |
| - |
| |
| - | </div>
| |
| - |
| |
| - | <div class="productxx">
| |
| - |
| |
| - |
| |
| - | <div class="clear"></div>
| |
| - | </div>
| |
| - | </div>
| |
| - | <div class="clear"></div>
| |
| - | </div>
| |
| - | </div>
| |
| - | <div id="footerxx">
| |
| - | <div id="copyright">
| |
| - | <span> iGEM 2009 <br /> </span>
| |
| - | </div>
| |
| - | <div id="payment"><img src="http://igem2009hkust.fileave.com/wiki/template/12092009/images/HKUSTLogo.jpg" alt="paypal" /></div>
| |
| - | </div>
| |
| - | <div id="footerend"></div>
| |
| - | </div>
| |
| - | </bodyxx>
| |
| - | </html>
| |
"
