Team:UC Davis

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Homepage_UCdavis

            It is estimated that about one in every 133 Americans suffer from an autoimmune disorder called Celiac Disease (14, 11). Celiac Disease is a condition where the small intestines of an affected individual cannot digest gliadin, a protein present in gluten. When consumed, gliadin kick starts immune system responses, whose side-effects are, but not limited to abdominal pain, chronic diarrhea and vomiting (14). One of our teammate’s friends is currently suffering from this illness, which motivated us to look into Celiac Disease as the focus of our project. Currently, the only accepted treatment for this disorder is adhering to a gluten-free diet (14, 12). This can be very difficult as great varieties of food contain gluten. This inspired us to imagen an alrtenative treatment base on a probiotic organism that could survive and take residence in the stomach where it would secrete an enzyme that can degrade gliadin.
           Then the design elements of this organism should be able to satisfy at least two main criteria. First, it should be able to survive ONLY in the stomach and, secondly, secrete an enzyme that can degrade gliadin. We invision that these parts would not only be useful for our porpose probiotic, but could be useful to number of other projects.
       We have decided to focus our summer project on building two key elements required for our “dream bug”. Therefore, our project has been split into two tasks:
                1. Produce an inducible secretion system
                2. Construct a biological pH sensor limiting this secretion system to the system

UC Davis iGEM team is sponsors:

Special thanks to Suzy Fenton,Wayne Fenton, Jeanne Joe-Fenton and Wayne Fenton Jr.
Also we thank Charles H. Halsted for reviewing our material regarding celiac disease.

@@ Line 86: / Line 86: @@
 One of
 our teammate’s friends is currently suffering from this illness, which
-interested us to look into Celiac Disease as the focus of our project.
+motivated us to look into Celiac Disease as the focus of our project.
 Currently, the only accepted treatment for this disorder is adhering to
 a
 gluten-free diet (14, 12). This can be very difficult as great
 varieties of
-food contain gluten. This inspired us to design a probiotic organism
+food contain gluten. This inspired us to imagen an alrtenative
+treatment base on a probiotic organism
 that could
 survive and take residence in the stomach where it would secrete an
@@ Line 97: / Line 98: @@
 can degrade gliadin.</big></span><big style="font-weight: bold;"><span
 style="font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;"><br>
-&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp; &nbsp;&nbsp; This synthetically
+&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp; &nbsp;&nbsp; Then the design
-engineered bug should be able to satisfy at least two main criteria.
+elements of this organism should be able to satisfy at least two main
+criteria.
 First, it
 should be able to survive ONLY in the stomach and, secondly, secrete an
 enzyme
-that can degrade gliadin<i>.</i>&nbsp; </span><span
+that can degrade gliadin<i>.</i> We invision that these parts would not
+only be useful for our porpose probiotic, but could be useful to number
+of other projects.</span><span
 style="font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;"><o:p></o:p></span><br>
 </big><span style="font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;"><big
@@ Line 168: / Line 172: @@
 style="width: 182px; height: 108px;" alt=""
 src="https://static.igem.org/mediawiki/2009/c/c6/UCDAVIS_genome_center.jpg"><br>
-<font size="-1">Special thank to <span style="font-weight: bold;">Suzy
+<font size="-1">Special thanks to <span style="font-weight: bold;">Suzy
 Fenton</span>,<span style="font-weight: bold;">Wayne Fenton, Jeanne
 Joe-Fenton </span>and<span style="font-weight: bold;"> Wayne Fenton Jr.</span>