Team:LCG-UNAM-Mexico:BSD
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Results by Yin,2002 suggested an efficient way to reduce phage cycle efficieny: "...phage growth was found to be most sensitive to the host translation machinery, specifically, the level and elongation rate of the ribosomes."<br> | Results by Yin,2002 suggested an efficient way to reduce phage cycle efficieny: "...phage growth was found to be most sensitive to the host translation machinery, specifically, the level and elongation rate of the ribosomes."<br> | ||
- | We added to our [[Team:LCG-UNAM-Mexico:WTM | Wild type Molecular Model]] the action of colicin E3 (rRNAsa): cleavage of rRNA of 16s subunit of the ribosome. | + | We added to our [[Team:LCG-UNAM-Mexico:WTM | Wild type Molecular Model]] the action of colicin E3 (rRNAsa): cleavage of rRNA of 16s subunit of the ribosome. We couldn't find the rate of this reaction in the literature so we decided to perform a sensitivity analysis: change the reaction rate over a wide range of values and see wether the burst size is reduced significantly or not.<br> |
- | The image on the | + | The image on the left shows the results of the sensitivity analysis: Burst Size was reduced to 0 when the ribosome inactivation rate takes values greater or equal than 10e-4. When the rate inactivation is 10e-5 the mean burst size is 5.8. |
+ | Using the BSD distribution with mean=5.8 in the [[Team:LCG-UNAM-Mexico:CA | Cellular Automata simulations]] we observed that the bacteria population, after a brave struggle with phages, sadly dies. This result was expected since the latency period is smaller than the duplication time and each infected bacterio will produce an average of 6 phages!<br> | ||
+ | Our system work as expected for burst size values less or equal to 1. Sensitivity analysis shows that our system works for a wide range of values for the ribosome inactivation rate but even a small burst size value like 6 will eventually kill the whole population. | ||
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==References== | ==References== |
Latest revision as of 01:59, 22 October 2009