Team:BCCS-Bristol/Modeling/Population Dynamics

From 2009.igem.org

(Difference between revisions)
(BSim Verify Some Concepts)
(Removing all content from page)
 
(6 intermediate revisions not shown)
Line 1: Line 1:
-
{{:Team:BCCS-Bristol/Header}}
 
-
==Population Dynamics==
 
-
 
-
We are trying to find answers to these problems and questions:
 
-
----
 
-
[http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=98908&blobtype=pdf Morphogenesis E.Coli]
 
-
----
 
-
*Bacteria change [http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2134870&blobtype=pdf size].
 
-
**Minimum size
 
-
***When the bacterium will be at the minimum size?
 
-
***How fast the bacterium increase its dimension?
 
-
**Maximum size
 
-
***When the bacterium will be to the maximum size?
 
-
**There is same relationship between [http://books.google.co.uk/books?id=0SPMLpTxGpMC&pg=PA51&lpg=PA51&dq=e.coli+size+velocity+motion&source=bl&ots=rqCBRQ1IN1&sig=__zft5KeWbLpUodXwGcyvnOBQtM&hl=en&ei=ZUhkSprSKcaZjAeN6IUC&sa=X&oi=book_result&ct=result&resnum=5 velocity and size] ?
 
-
**Relationship beetwen size/time/growth rate
 
-
----
 
-
*Separation.
 
-
**When this happen?
 
-
**Where the bacterium get placed?
 
-
***Maybe following the [http://books.google.co.uk/books?id=DjdgXGLoJY8C&printsec=frontcover&dq=E.+coli+in+motion++By+Howard+C.+Berg&source=gbs_similarbooks_s&cad=1 bacterium motion] ?
 
-
***Random?
 
-
***Fluid dynamics?
 
-
**Motion properties after the separation.
 
-
***Velocity after separation.
 
-
**The two bacteria after the separation have the same size?
 
-
----
 
-
*Genetic information
 
-
**After the separation the two bacteria have the same genetic properties:
 
-
***same replication time distribution?
 
-
***or the new one has a normal/uniform distribution on the normal/uniform distribution of the oldest one?
 
-
----
 
-
*[http://aem.asm.org/cgi/reprint/71/12/7920 Growth]
 
-
**Rate of growth
 
-
**Connection between the rate of duplication and the growth phase.
 
-
----
 
-
*Standing phase
 
-
**One bacterium can "kill" another one to make its replication?
 
-
***If yes which one is going to die?
 
-
----
 
-
*Environment
 
-
**we can try to model a variable condition of the environment:
 
-
***100% Suitable for the replication of the bacteria
 
-
***80% Suitable for the replication of the bacteria
 
-
***and so on...
 
-
----
 
-
*[http://jon.visick.faculty.noctrl.edu/research/aging.htm Growth Phase]
 
-
*[http://www.science-projects.com/SteadyState/SSProjects.htm Steady State]
 
-
----
 
-
*[http://www.ecoli-model.com/index_files/Page382.html Growth and Environments]
 
-
----
 
-
 
-
==BSim Verify Some Concepts==
 
-
*Collision (Distance calculation)
 
-
*Draw an element smoller than bacterium
 
-
*Rescale all BSim?
 
-
*Increase the lifeTime for each bacterium every timeStep?
 
-
 
-
==BSim Fixed Problems==
 
-
*Now we can drow shap using a "double" precision and not "int" precision
 
-
 
-
===Problems===
 
-
The most popular replication time for an E.Coli is about 20/25 minutes.<br\>
 
-
Can our simulation take so long time?<br\>
 
-
How can we simulate on "world" day with 400 bacteria?
 

Latest revision as of 00:06, 21 October 2009