Team:Brown/Team

From 2009.igem.org

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{| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center"
 
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!align="center"|[[Team:Brown|Home]]
 
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!align="center"|[[Team:Brown/Team|The Team]]
 
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!align="center"|[[Team:Brown/Project|The Project]]
 
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!align="center"|[[Team:Brown/Parts|Parts Submitted to the Registry]]
 
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!align="center"|[[Team:Brown/Modeling|Modeling]]
 
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!align="center"|[[Team:Brown/Notebook|Notebook]]
 
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|The 2009 Brown iGEM Team consists of 9 undergraduates from diverse backgrounds in science and engineering. We are mentored by Brown graduate students, postdocs, iGEM alumni, and faculty. With support from Brown UTRA Scholarships, we are working on our project in the Multi Disciplinary Lab over the summer.
 
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This year's team members are:
 
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Will Allen '12,
 
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Michael Chang '11,
 
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Stephanie Cheung '11,
 
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Ashley Kim '11,
 
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Flora Ko '12,
 
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Minoo Ramanathan '11,
 
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Ahmad Rana '11,
 
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Elias Scheer '12,
 
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Indu Voruganti '12
 
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The 2009 Brown iGEM Team aims to treat allergic rhinitis by engineering Staphylococcus epidermidis to secrete a histamine binding protein in response to elevated histamine concentrations during an allergic attack. The histamine-binding protein, rEV131, has been cloned from a species of tick,Rhipicephalus appendiculatus. rEV131 binds histamine with an extreme high affinity, and normally functions to prevent the inflammatory response while the tick sucks blood. We are transforming the gene for rEV131 into an endogenous nasal flora, S. epidermidis. rEV131 will have a secretion tag specific for S. epidermidis.
 
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Additionally, to synchronize rEV131 production with elevation of histamine, we are engineering a novel histamine receptor, via mutagenic PCR. We are mutating periplasmic receptors normally linked to gene transcription. The eventual goal is to link this histamine-responsive receptor to activation of an operon that promotes transcription of rEV131.
 
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Although S. epidermidis is a non-pathogenic specimen, additional safety precautions are being taken to control over-proliferation. When S. epidermidis reaches a certain population threshold, it begins to produce hazardous biofilms. We have cloned this population sensor, however, and placed its promoter over a DNA gyrase poison, cuing its "suicide" when populations have reached a dangerous level.
 
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[[Image:About-brown-igem-bar-1.png]]
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The Brown iGEM Lab is entirely student-run and consists of nine Brown University undergraduates. We began our training last spring with a lab course in Synthetic Biology. Under the gracious support of the Brown Undergraduate Teaching and Research Award (UTRA) Program and funding from various other academic departments, we were able to work throughout the summer on our project. Though the project's generation and implementation was an entirely student-directed process, the team owes much of its academic and research support to the faculty and graduate student advisers that helped make everything possible. Here at Brown, we pride ourselves in upholding the ideals set out by the iGEM competition, namely that the project we have set out to create is fully our own (from creation to completion) and that each student involved in the program be afforded his/her full opportunity to both learn and contribute in the lab. Therefore, in the true spirit of Synthetic Biology, our team's project this year works hard to reflect the many different research backgrounds contributed by its nine individual members; elements of electrical engineering, electrochemistry, genetics, and microbiology are incorporated.
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== '''Who we are''' ==
 
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'''Advisors:'''
'''Advisors:'''
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*''' Advisor ''':    Dr. Gary Wessel
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*''' Faculty Advisor ''':    Dr. Gary Wessel, Professor of Biology, Bio Med Molecular, Cellular Biology Biochemistry 
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*'''Grad Student ''':    Adrian Reich
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*'''Graduate Student Advisor ''':    Adrian Reich, Graduate Student,  Bio-Med (Bio)
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*'''Graduate Student Advisor ''':    Diana Donovan, Graduate Student, Bio-Med (Bio)
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'''Undergrads:'''
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'''Undergraduate Students:'''
*'''William Allen''': Will Allenquot
*'''William Allen''': Will Allenquot
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<gallery>
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Image:Garywessel.jpg|Dr. Gary Wessel
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Image:Adrianreich.jpg|Adrian Reich
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Image:Diana D.JPG|Diana Donovan
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</gallery>
<gallery>
<gallery>
Image:Will.jpg|Will Allen
Image:Will.jpg|Will Allen
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Image:flora.jpg|Flora Ko
Image:flora.jpg|Flora Ko
Image:eli.jpg|Eli Scheer
Image:eli.jpg|Eli Scheer
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Image:ahmad.jpg|Ahmad Rana
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Image:Ahmad_Rana.jpg|Ahmad Rana
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Image:minoo.jpg|Minoo Ramanthan
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Image:minoo.jpg|Minoo Ramanathan
Image:indu.jpg|Indu Voruganti
Image:indu.jpg|Indu Voruganti
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Team Brown is proud to collaborate with Team Valencia in raising awareness about '''human practices''' , '''safety''', '''ethics''', '''patents''', etc. in synthetic biology. Our team had 100% participation in the survey prepared by Team Valencia.
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[[Image:V_Brown.jpg]]

Latest revision as of 05:11, 7 November 2009




About-brown-igem-bar-1.png The Brown iGEM Lab is entirely student-run and consists of nine Brown University undergraduates. We began our training last spring with a lab course in Synthetic Biology. Under the gracious support of the Brown Undergraduate Teaching and Research Award (UTRA) Program and funding from various other academic departments, we were able to work throughout the summer on our project. Though the project's generation and implementation was an entirely student-directed process, the team owes much of its academic and research support to the faculty and graduate student advisers that helped make everything possible. Here at Brown, we pride ourselves in upholding the ideals set out by the iGEM competition, namely that the project we have set out to create is fully our own (from creation to completion) and that each student involved in the program be afforded his/her full opportunity to both learn and contribute in the lab. Therefore, in the true spirit of Synthetic Biology, our team's project this year works hard to reflect the many different research backgrounds contributed by its nine individual members; elements of electrical engineering, electrochemistry, genetics, and microbiology are incorporated.


Advisors:

  • Faculty Advisor : Dr. Gary Wessel, Professor of Biology, Bio Med Molecular, Cellular Biology Biochemistry
  • Graduate Student Advisor : Adrian Reich, Graduate Student, Bio-Med (Bio)
  • Graduate Student Advisor : Diana Donovan, Graduate Student, Bio-Med (Bio)

Undergraduate Students:

  • William Allen: Will Allenquot
  • Michael Chang: MC Mastermix
  • Stephanie Cheung: Stephylococcus
  • Ashley Kim: Ashley Kimwipe
  • Flora War War Ko: Nasal Flora
  • Elias Scheer: E.coli Scheer
  • Minoo Ramanathan: Minoo Prep
  • Ahmad Rana: Ahmad Ran-a-gel
  • Indu Voruganti: The INDUcer

Dr. Gary Wessel

Adrian Reich

Diana Donovan

Will Allen

Michael Chang

Steph Cheung

Ashley Kim

Flora Ko

Eli Scheer

Ahmad Rana

Minoo Ramanathan

Indu Voruganti

Team Brown is proud to collaborate with Team Valencia in raising awareness about '''human practices''' , '''safety''', '''ethics''', '''patents''', etc. in synthetic biology. Our team had 100% participation in the survey prepared by Team Valencia.
Retrieved from "http://2009.igem.org/Team:Brown/Team"