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| - | __NOTOC__
| + | {{Template:LCG_top_Netscape}}<!--Do not remove the first and last lines in this page!--> |
| - | <html> | + | |
| | | | |
| | + | {| |
| | + | |-valign="top" border="0" |
| | + | |width="900px" style="padding: 0 20px 0 0;"| |
| | | | |
| - | <style>
| |
| - | h1.firstHeading { display: none; }
| |
| | | | |
| - | p {text-align: justify;}
| + | ='''The Project in a nutshell'''= |
| | | | |
| - | a:link { color: #659D32; text-decoration: none}
| |
| - | a:visited { color#659D32; text-decoration: none}
| |
| - | a:hover { color:#f29400; text-decoration: none}
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| - | a:active { color:#f29400; text-decoration: none}
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| | | | |
| - | #bodyContent { padding: 10px auto; width: 900px; margin: auto; clear: none; }
| + | Bacteriophage infection represents an interesting process in microbiology and industry. The idea of being able to contend at a population level with such infections is the main motivation for the development of our project.<br> |
| | | | |
| - | table#team_members { text-align: justify; border: 0; }
| + | We propose a population level approach relaying on a defense system delivered by an engineered version of the enterobacteria phage P4. The purpose of the defense construction is to modify bacteria in order to hold back the process of infection by triggering a cellular death response when a cell encounters a specific component of the infective phage. Such response will be fast enough to stop the formation process of viral particles, thus preventing the phage proliferation and population decline.<br> |
| - | table#team_members h2, table#team_members h3 { clear: both; }
| + | |
| | | | |
| - | /*-----------------------------------------------------------------------------------------------*/
| + | The delivery system takes advantage of the satellite properties of P4 phage. This means that a P4 phage engineered with the defense construction will be able to infect an ''E.coli'' strain which harbors some genes from helper phage P2 that are used for complementing and completing P4 life cycle, hence creating a production line of our version of P4.<br> |
| - | div.MenuBar ul li ul.DropDownMenu {
| + | Besides, the defense system will consist of DNA and RNA degradation by toxins which will be transcribed by T3 or T7 RNA-Polymerases fast enough to stop phage assembly and scattering in the environment. Simultaneously, a quorum sensing signal will be diffusing to the non-infected bacteria acting as a transcriptional activator of an antisense RNA against bacteriophage's transcriptional machinery , hence "warning" the population to prepare against further T3 or T7 infection.<br> |
| - | display: none; /* Hides all drop-down menus. */
| + | <br> |
| | + | We implemented a stochastic [[Team:LCG-UNAM-Mexico: | multi-scale model]]. The model will simulate the behaviour at the intracellular scale using [[Team:LCG-UNAM-Mexico:Molecular model | stochastic molecular simulations]] and at the populations scale using a [[Team:LCG-UNAM-Mexico:CA | Cellular Automata]] and a [[Team:LCG-UNAM-Mexico:odes | system of ODE's]]. <br> Simulations results are in good agreement with existing experimental data. Thanks to the structure and design of the model this can be easily modified in order to simulate infection dynamics for different bacteria and phages. Furthermore, our Molecular model can be used as a reliable tool for sampling biomolecules distributions involved in phage infection processes. <br> |
| | | | |
| | + | <html> |
| | + | <header> |
| | + | <script language="JavaScript"> |
| | + | function mouseOver_comic(){ |
| | + | document.getElementById("comic").src ="https://static.igem.org/mediawiki/2009/6/60/Comic_LCG_bb.png"; |
| | } | | } |
| - | /*
| + | function mouseOut_comic(){ |
| - | li:hover works in IE7 and FF2.
| + | document.getElementById("comic").src ="https://static.igem.org/mediawiki/2009/a/a8/Comic_LCG_ba.png"; |
| - | a:hover works in IE6 and FF2.
| + | |
| - | a:hover breaks li:hover in FF2.
| + | |
| - | */
| + | |
| - | div.MenuBar ul li:hover ul.DropDownMenu li ul.SideMenu,
| + | |
| - | div.MenuBar ul li a:hover ul.DropDownMenu li a ul.SideMenu {
| + | |
| - | display: none; /* Hides all side menus. */
| + | |
| - | }
| + | |
| - | /*------------------------------------------------------------------------------------- Menu Bar */ | + | |
| - | div.MenuBar {
| + | |
| - | font: arial, helvetica, sans-serif;
| + | |
| - | height: 30px;
| + | |
| - | width: 900px;
| + | |
| - | background: #659D32;
| + | |
| - |
| + | |
| | } | | } |
| - | div.MenuBar ul {
| |
| - | font: arial, helvetica, sans-serif;
| |
| - | text-align: center;
| |
| - | margin: 0.5em auto;
| |
| | | | |
| - | background: #659D32;
| |
| - | }
| |
| - | div.MenuBar ul li {
| |
| - | font: arial, helvetica, sans-serif;
| |
| - | display: block;
| |
| - | padding: 0;
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| - | margin: 0;
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| - | font-size: 1.3em;
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| - | float: left;
| |
| - | background: #659D32;
| |
| - | text-align: center;
| |
| - | width: 107px;
| |
| - | position: relative; /* Sets the positioning context for each drop-down menu. */
| |
| - | }
| |
| | | | |
| - | div.MenuBar ul li a {
| + | </script> |
| - | font: arial, helvetica, sans-serif;
| + | </header> |
| - | display: block;
| + | |
| - | background: #659D32;
| + | |
| - | height: 22px; /* Keep height + padding-top + padding-bottom sync with the menu bar height. */
| + | |
| - | color: #ffffff;
| + | |
| - | padding-top: 4px;
| + | |
| - | padding-bottom: 4px;
| + | |
| - | padding-left: 1em; /* Sets the left space between top-level items. */
| + | |
| - | padding-right: 1em; /* Sets the right space between top-level items. */
| + | |
| - | text-decoration: none;
| + | |
| - | }
| + | |
| | | | |
| - | /*------------------------------------------------------------------------------ Drop-Down Menus */
| + | <style> |
| - | div.MenuBar ul li:hover ul.DropDownMenu,
| + | #bodyContent { padding: 10px auto; width: 1000px; margin: auto; clear: none; } |
| - | div.MenuBar ul li a:hover ul.DropDownMenu {
| + | a:link { color: #659D32; text-decoration: none} |
| - | display: block;
| + | a:visited { color:#659D32; text-decoration: none} |
| - | width: 13em; /* Drop-down menu width.
| + | a:hover { color:#f29400; text-decoration: none} |
| - | Use MenuTailor.css to customize. */
| + | a:active { color:#f29400; text-decoration: none} |
| - | padding: 1px; /* Sets the drop-down menu "effective border" width. */
| + | |
| - | position: absolute;
| + | |
| - | top: 22px; /* Places the drop-down menu under the menu bar.
| + | |
| - | Keep it sync with the menu bar height. */
| + | |
| - | left: 0; /* Aligns the drop-down menu to its top-level item. */
| + | |
| - | background-color: #659D32; /* Selected item. */
| + | |
| - | color: #FFFFFF;
| + | |
| | | | |
| - | }
| + | </style> |
| - | div.MenuBar ul li:hover ul.DropDownMenu li a,
| + | |
| - | div.MenuBar ul li a:hover ul.DropDownMenu li a {
| + | |
| - | width: 10em; /* Keep it sync with the drop-down menu width.
| + | |
| - | Use MenuTailor.css to customize. */
| + | |
| - | height: 1em;
| + | |
| - | padding-left: 0;
| + | |
| - | padding-right: 0;
| + | |
| - | background-color: #659D32; /* Selected item. */
| + | |
| - | color: #FFFFFF;
| + | |
| - | }
| + | |
| - | ul.DropDownMenu li a span {
| + | |
| - | display: block;
| + | |
| - | padding-left: 0.75em; /* Sets the left space of each drop-down menu item. */
| + | |
| - | padding-right: 0.25em; /* Sets the right space of each drop-down menu item. */
| + | |
| - | text-align: right; /* Aligns the >> symbol to the right. */
| + | |
| - | }
| + | |
| - | ul.DropDownMenu li a span span {
| + | |
| - | float: left; /* Aligns the text (back) to the left. */
| + | |
| - | font: 12px arial, helvetica, sans-serif; /* Required for IE55. */
| + | |
| - | height: 20px;
| + | |
| - | color: #FFFFFF;
| + | |
| - | }
| + | |
| - | /*----------------------------------------------------------------------------------- Side Menus */
| + | |
| - | div.MenuBar ul li:hover ul.DropDownMenu li:hover ul.SideMenu,
| + | |
| - | div.MenuBar ul li a:hover ul.DropDownMenu li a:hover ul.SideMenu {
| + | |
| - | display: block;
| + | |
| - | width: 11em; /* Side menu width.
| + | |
| - | Use MenuTailor.css to customize. */
| + | |
| - | padding: 1px; /* Sets the side menu "effective border" width. */
| + | |
| - | position: absolute;
| + | |
| - | top: -1px; /* Aligns the side menu to its drop-down menu item.
| + | |
| - | Keep it sync with the side menu "effective border" width. */
| + | |
| - | left: 13em; /* Places the side menu to the right of the drop-down menu.
| + | |
| - | Keep it sync with the drop-down menu width.
| + | |
| - | Use MenuTailor.css to customize. */
| + | |
| - | }
| + | |
| - | div.MenuBar ul li:hover ul.DropDownMenu li:hover ul.SideMenu li a,
| + | |
| - | div.MenuBar ul li a:hover ul.DropDownMenu li a:hover ul.SideMenu li a {
| + | |
| - | width: 11em; /* Keep it sync with the side menu width.
| + | |
| - | Use MenuTailor.css to customize. */
| + | |
| - | }
| + | |
| - | div.MenuBar ul li ul.DropDownMenu li ul.SideMenu li a span {
| + | |
| - | padding-left: 1.5em; /* Sets the left space of each side menu item. */
| + | |
| - | padding-right: 0.5em; /* Sets the right space of each side menu item. */
| + | |
| - | text-align: left;
| + | |
| - | }
| + | |
| - | /*----------------------------------------------------------------------------- Browser Specific */
| + | |
| - | * html div.MenuBar ul li a {
| + | |
| - | float: left; /* Required for IE55 and IE6.
| + | |
| - | Breaks O9.
| + | |
| - | Hidden (* html) from non-IE browsers. */
| + | |
| - | }
| + | |
| - | * html ul.DropDownMenu li a:hover {
| + | |
| - | cursor: hand; /* Required for IE55.
| + | |
| - | Hidden (* html) from non-IE browsers. */
| + | |
| - | }
| + | |
| - | ul.DropDownMenu li a:hover {
| + | |
| - | cursor: pointer; /* Required for IE6 and IE7.
| + | |
| - | Hidding it (* html) from non-IE browsers breaks IE7!
| + | |
| - | }
| + | |
| - | * html div.MenuBar a:hover {
| + | |
| - | text-decoration: none; /* Required for IE55 and IE6.
| + | |
| - | Hidden (* html) from non-IE browsers. */
| + | |
| - | }
| + | |
| - | * html div.MenuBar ul li table,
| + | |
| - | * html div.MenuBar ul li table td {
| + | |
| - | border: 0; /* Required for IE55 and IE6.
| + | |
| - | Hidden (* html) from non-IE browsers. */
| + | |
| - | }
| + | |
| - | /*------------------------------------------------------------------------------- Default Colors */
| + | |
| - | div.MenuBar {
| + | |
| - | background-color: Menu;
| + | |
| - | border-bottom: 1px solid ButtonShadow;
| + | |
| - | }
| + | |
| - | div.MenuBar a {
| + | |
| - | background-color: Menu; /* Top-level unselected items. */
| + | |
| - | color: MenuText;
| + | |
| - | }
| + | |
| - | div.MenuBar ul li:hover a,
| + | |
| - | div.MenuBar ul li a:hover {
| + | |
| - | color: #ea7f16;
| + | |
| - | background-color: Highlight; /* Top-level selected item. */
| + | |
| - | color: HighlightText;
| + | |
| - | }
| + | |
| - | /*...............................................................................................*/
| + | |
| - | div.MenuBar ul li:hover ul.DropDownMenu,
| + | |
| - | div.MenuBar ul li a:hover ul.DropDownMenu {
| + | |
| - | background-color: ButtonShadow; /* Sets the drop-down menu "effective border" color. */
| + | |
| - | }
| + | |
| - | div.MenuBar ul li:hover ul.DropDownMenu li a,
| + | |
| - | div.MenuBar ul li a:hover ul.DropDownMenu li a {
| + | |
| - | background-color: Menu; Drop-down menu unselected items.
| + | |
| - | Sets the drop-down menu "effective background" color. */
| + | |
| - | color: MenuText;
| + | |
| - | }
| + | |
| - | div.MenuBar ul li:hover ul.DropDownMenu li:hover a,
| + | |
| - | div.MenuBar ul li a:hover ul.DropDownMenu li a:hover {
| + | |
| - | background-color: Highlight; /* Drop-down menu selected item. */
| + | |
| - | color: HighlightText;
| + | |
| - | }
| + | |
| - | /*...............................................................................................*/
| + | |
| - | div.MenuBar ul li:hover ul.DropDownMenu li:hover ul.SideMenu,
| + | |
| - | div.MenuBar ul li a:hover ul.DropDownMenu li a:hover ul.SideMenu {
| + | |
| - | background-color: ButtonShadow; /* Sets the side menu "effective border" color. */
| + | |
| - | }
| + | |
| - | div.MenuBar ul li:hover ul.DropDownMenu li:hover ul.SideMenu li a,
| + | |
| - | div.MenuBar ul li a:hover ul.DropDownMenu li a:hover ul.SideMenu li a {
| + | |
| - | background-color: Menu; /* Side menu unselected items.
| + | |
| - | Sets the side menu "effective background" color. */
| + | |
| - | color: MenuText;
| + | |
| - | }
| + | |
| - | div.MenuBar ul li:hover ul.DropDownMenu li:hover ul.SideMenu li a:hover,
| + | |
| - | div.MenuBar ul li a:hover ul.DropDownMenu li a:hover ul.SideMenu li a:hover {
| + | |
| - | background-color: Highlight; /* Side menu selected item. */
| + | |
| - | color: HighlightText;
| + | |
| - | }
| + | |
| - | /*-----------------------------------------------------------------------------------------------*/
| + | |
| - | /*Script-Free 3-Level Menu 1.2 Tailor
| + | |
| - | www.CesarDaniel.info
| + | |
| - | /*-------------------------------------------------------------------------------------- General */
| + | |
| - | body {
| + | |
| - | background: white;
| + | |
| - | color: #659D32;
| + | |
| - | margin: 0;
| + | |
| - | border: 0;
| + | |
| - | padding: 0;
| + | |
| - | }
| + | |
| | | | |
| - |
| |
| - | div.MenuBar {
| |
| - | font: 13px arial, helvetica, sans-serif;
| |
| - | }
| |
| - | div.MenuBar ul {
| |
| - | font: 13px arial, helvetica, sans-serif; /* Required for IE55. */
| |
| - | }
| |
| - | /*--------------------------------------------------------------------------------------- Colors */
| |
| - | div.MenuBar {
| |
| - | background-color: #659D32; /* Selected item. */
| |
| - | color: #FFFFFF;
| |
| - | border-bottom: 1px solid ButtonShadow;
| |
| - | }
| |
| - | div.MenuBar a,
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| - | div.MenuBar ul li:hover ul.DropDownMenu li a,
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| - | div.MenuBar ul li a:hover ul.DropDownMenu li a,
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| - | div.MenuBar ul li:hover ul.DropDownMenu li:hover ul.SideMenu li a,
| |
| - | div.MenuBar ul li a:hover ul.DropDownMenu li a:hover ul.SideMenu li a {
| |
| - | background-color: #659D32; /* Selected item. */
| |
| - | color: #FFFFFF;
| |
| - | }
| |
| - | div.MenuBar ul li:hover a,
| |
| - | div.MenuBar ul li a:hover,
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| - | div.MenuBar ul li:hover ul.DropDownMenu li:hover a,
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| - | div.MenuBar ul li a:hover ul.DropDownMenu li a:hover,
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| - | div.MenuBar ul li:hover ul.DropDownMenu li:hover ul.SideMenu li a:hover,
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| - | div.MenuBar ul li a:hover ul.DropDownMenu li a:hover ul.SideMenu li a:hover {
| |
| - | background-color: #003300; /* Selected item. */
| |
| - | color: #FFFFFF;
| |
| - | }
| |
| - | div.MenuBar ul li:hover ul.DropDownMenu,
| |
| - | div.MenuBar ul li a:hover ul.DropDownMenu,
| |
| - | div.MenuBar ul li:hover ul.DropDownMenu li:hover ul.SideMenu,
| |
| - | div.MenuBar ul li a:hover ul.DropDownMenu li a:hover ul.SideMenu {
| |
| - | background-color: ButtonShadow; /* Sets the drop-down and side menus "effective border" color. */
| |
| - | }
| |
| - | /*--------------------------------------------------------------------------------------- Widths */
| |
| - | /*
| |
| - |
| |
| - | /*
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| - | Menu Bar 1
| |
| - | Drop-Down Menu #2
| |
| - | */
| |
| - | div.MenuBar#navi ul li:hover ul.DropDownMenu#MB1-DDM4,
| |
| - | div.MenuBar#navi ul li a:hover ul.DropDownMenu#MB1-DDM4,
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| - | div.MenuBar#navi ul li:hover ul.DropDownMenu#MB1-DDM4 li a,
| |
| - | div.MenuBar#navi ul li a:hover ul.DropDownMenu#MB1-DDM4 li a {
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| - | width: 11em; /* Drop-down menu width. */
| |
| - | }
| |
| - | div.MenuBar#navi ul li:hover ul.DropDownMenu#MB1-DDM5,
| |
| - | div.MenuBar#navi ul li a:hover ul.DropDownMenu#MB1-DDM5,
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| - | div.MenuBar#navi ul li:hover ul.DropDownMenu#MB1-DDM5 li a,
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| - | div.MenuBar#navi ul li a:hover ul.DropDownMenu#MB1-DDM5 li a {
| |
| - | width: 12em; /* Drop-down menu width. */
| |
| - | }
| |
| - |
| |
| - | /*...............................................................................................*/
| |
| - | /*
| |
| - | Menu Bar 1
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| - | Drop-Down Menu #2
| |
| - | Side Menu #1
| |
| - | */
| |
| - | div.MenuBar#navi ul li:hover ul.DropDownMenu li:hover ul.SideMenu#MB1-DDM2-SM1,
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| - | div.MenuBar#navi ul li a:hover ul.DropDownMenu li a:hover ul.SideMenu#MB1-DDM2-SM1 {
| |
| - | left: 15.5em !important; /* Places the side menu to the right of the drop-down menu.
| |
| - | Keep it sync with the drop-down menu width. */
| |
| - | }
| |
| - | div.MenuBar#navi ul li:hover ul.DropDownMenu li:hover ul.SideMenu#MB1-DDM2-SM1,
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| - | div.MenuBar#navi ul li a:hover ul.DropDownMenu li a:hover ul.SideMenu#MB1-DDM2-SM1,
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| - | div.MenuBar#navi ul li:hover ul.DropDownMenu li:hover ul.SideMenu#MB1-DDM2-SM1 li a,
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| - | div.MenuBar#navi ul li a:hover ul.DropDownMenu li a:hover ul.SideMenu#MB1-DDM2-SM1 li a {
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| - | width: 10em; /* Side menu width. */
| |
| - | }
| |
| - | /*...............................................................................................*/
| |
| - | /*
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| - | Menu Bar 1
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| - | Drop-Down Menu #2
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| - | Side Menu #2
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| - | */
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| - | div.MenuBar#navi ul li:hover ul.DropDownMenu li:hover ul.SideMenu#MB1-DDM2-SM2,
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| - | div.MenuBar#navi ul li a:hover ul.DropDownMenu li a:hover ul.SideMenu#MB1-DDM2-SM2 {
| |
| - | left: 15.5em !important; /* Places the side menu to the right of the drop-down menu.
| |
| - | Keep it sync with the drop-down menu width. */
| |
| - | }
| |
| - | div.MenuBar#navi ul li:hover ul.DropDownMenu li:hover ul.SideMenu#MB1-DDM2-SM2,
| |
| - | div.MenuBar#navi ul li a:hover ul.DropDownMenu li a:hover ul.SideMenu#MB1-DDM2-SM2,
| |
| - | div.MenuBar#navi ul li:hover ul.DropDownMenu li:hover ul.SideMenu#MB1-DDM2-SM2 li a,
| |
| - | div.MenuBar#navi ul li a:hover ul.DropDownMenu li a:hover ul.SideMenu#MB1-DDM2-SM2 li a {
| |
| - | width: 10em; /* Side menu width. */
| |
| - | }
| |
| - | /*...............................................................................................*/
| |
| - | /*
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| - | Menu Bar 1
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| - | Drop-Down Menu #2
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| - | Side Menu #3
| |
| - | */
| |
| - | div.MenuBar#navi ul li:hover ul.DropDownMenu li:hover ul.SideMenu#MB1-DDM2-SM3,
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| - | div.MenuBar#navi ul li a:hover ul.DropDownMenu li a:hover ul.SideMenu#MB1-DDM2-SM3 {
| |
| - | left: 13em !important; /* Places the side menu to the right of the drop-down menu.
| |
| - | Keep it sync with the drop-down menu width. */
| |
| - | }
| |
| - | div.MenuBar#navi ul li:hover ul.DropDownMenu li:hover ul.SideMenu#MB1-DDM2-SM3,
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| - | div.MenuBar#navi ul li a:hover ul.DropDownMenu li a:hover ul.SideMenu#MB1-DDM2-SM3,
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| - | div.MenuBar#navi ul li:hover ul.DropDownMenu li:hover ul.SideMenu#MB1-DDM2-SM3 li a,
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| - | div.MenuBar#navi ul li a:hover ul.DropDownMenu li a:hover ul.SideMenu#MB1-DDM2-SM3 li a {
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| - | width: 10em; /* Side menu width. */
| |
| - | }
| |
| - | /*...............................................................................................*/
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| - |
| |
| - | </style>
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| | <body> | | <body> |
| - | <div id="header">
| |
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| |
| - | <div class='MenuBar' id="navi">
| |
| - | <ul>
| |
| - | <li>
| |
| - | <a href="https://2009.igem.org/Team:LCG-UNAM-Mexico" style="color: white">Home
| |
| - | <!--[if gt IE 6]><!--></a><!--<![endif]-->
| |
| - | <!--[if lt IE 7]><table border="0" cellpadding="0" cellspacing="0"><tr><td><![endif]-->
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| - | <!--[if lte IE 6]></td></tr></table></a><![endif]-->
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| - | </li>
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| - | <li>
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| - | <a href="https://2009.igem.org/Team:LCG-UNAM-Mexico" style="color: white">Team<!--[if gt IE 6]><!--></a><!--<![endif]-->
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| - | <!--[if lt IE 7]><table border="0" cellpadding="0" cellspacing="0"><tr><td><![endif]-->
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| - | <ul class="DropDownMenu" id="MB1-DDM6">
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| - | <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico"><span><span>Overview</span></span></a></li>
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| - | <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico"><span><span>Advisors</span></span></a></li>
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| - | <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico"><span><span>Undergrads</span></span></a></li>
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| - | <a href="https://2009.igem.org/Team:LCG-UNAM-Mexico" style="color: white">Project<!--[if gt IE 6]><!--></a><!--<![endif]-->
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| - | <!--[if lt IE 7]><table border="0" cellpadding="0" cellspacing="0"><tr><td><![endif]-->
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| - | <ul class="DropDownMenu" id="MB1-DDM1">
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| - | <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico"><span><span>Main Idea</span></span></a></li>
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| - | <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico"><span><span>Methods</span></span></a>
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| - | <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico"><span><span>Results</span></span></a></li>
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| - | <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico"><span><span>Parts></span></span><!--[if gt IE 6]><!--></a><!--<![endif]-->
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| - | <!--[if lt IE 7]><table border="0" cellpadding="0" cellspacing="0"><tr><td><![endif]-->
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| - | <ul class="SideMenu" id="MB1-DDM2-SM3">
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| - | <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico"><span>Registry</span></a></li>
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| - | <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico"><span>Characterization</span></a></li>
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| + | <a href="https://2009.igem.org/Team:LCG-UNAM-Mexico:Comic" ><img border="0" src="https://static.igem.org/mediawiki/2009/a/a8/Comic_LCG_ba.png" id="comic" onmouseover="mouseOver_comic()" onmouseout="mouseOut_comic()"></a> |
| - | <li>
| + | |
| - | <a href="https://2009.igem.org/Team:LCG-UNAM-Mexico " style="color: white"> Modelling< !--[if gt IE 6]><!--></a><!--<![endif]--> | + | |
| - | <!--[if lt IE 7]><table border="0" cellpadding="0" cellspacing="0"><tr><td><![endif]-->
| + | |
| - | <ul class="DropDownMenu" id="MB1-DDM3">
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| - | <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico"><span><span>Overview</span></span></a></li>
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| - | <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico"><span><span>Molecular Model</span></span></a></li>
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| - | <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico"><span><span>Population Model</span></span></a></li>
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| - | <a href="https://2009.igem.org/Team:LCG-UNAM-Mexico" style="color: white">Notebook
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| - | <!--[if gt IE 6]><!--></a><!--<![endif]-->
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| - | </ul>
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| - | | + | |
| - | </div>
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| | | | |
| | </body> | | </body> |
| | </html> | | </html> |
| | | | |
| - | {|
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| - | |-valign="top" border="0"
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| - | |width="650px" style="padding: 0 20px 0 0;"|
| |
| | | | |
| | + | |} |
| | | | |
| - | =='''The Project'''==
| + | ---- |
| | | | |
| - | Bacteriophage infection represents an interesting process in science and industry. The idea of being able to contend at a population level with such infections is the main motivation of the development of our project.
| |
| | | | |
| - | We plan to modify an Escherichia coli phage in order to deliver genetic material codifying for a construction against other phages, taking advantage of some of their own properties!!! The purpose of this construction is to make a bacterial to fight back against the spreading of some phage by triggering on a cellular death response when a cell encounters a specific component of the phage. Such response will be faster than the formation process of viral particles preventing the death of the bacterial population.
| + | <html> |
| | + | <header> |
| | | | |
| - | This population resistance can be seen as a sort of "vaccine" that will hold back the process of infection. The design of the delivery system includes the use the P4 phage and its auxiliary genes present in the P2 helper phage. In the case of the "vaccine" construct, the cellular death response will be induced by the presence of T3 or T7 RNA polymerases which will also turn on the transcription of toxines used for the degradation of DNA and RNA to stop the phage´s genetic material from assembling and scattering in the environment.
| + | <script language="JavaScript"> |
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| | + | document.getElementById("parts").src ="https://static.igem.org/mediawiki/2009/a/a4/Parts_a.png"; |
| | + | } |
| | | | |
| - | Furthermore, we will implement a stochastic population model based on the basic properties of the bacterial cells and the phages such as movement, reproduction, etc., this will allow us to simulate the infection processes and quantify the efficiency of our system. A possible extention of the system includes the expansion of an AHL signal through the quorum sensing system of Vibrio fischeri in which the population will be "warned" to prepare against the viral infection in the presence of T3 or T7.
| + | function mouseOver_res(){ |
| | + | document.getElementById("res").src ="https://static.igem.org/mediawiki/2009/3/35/Resources_b.png"; |
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| | + | document.getElementById("res").src ="https://static.igem.org/mediawiki/2009/9/93/Resources_a.png"; |
| | + | } |
| | | | |
| - | ==About us== | + | function mouseOver_des(){ |
| - | Hi, welcome to our site! We are students from the undergraduate program in Genomic Sciences which is part of the National Autonomous University of Mexico. We are working on the official version of the wiki. Here you will find advances and general information about our project.
| + | document.getElementById("des").src ="https://static.igem.org/mediawiki/2009/2/2a/Description_b.png"; |
| | + | } |
| | + | function mouseOut_des(){ |
| | + | document.getElementById("des").src ="https://static.igem.org/mediawiki/2009/3/3e/Description_a.png"; |
| | + | } |
| | | | |
| - | |width="250px"|
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| | + | } |
| | | | |
| | + | </script> |
| | + | </header> |
| | | | |
| - | | + | <body> |
| - | ==News== | + | <br><br> |
| - | | + | <table border="0" align="center" width="600" cellpadding="50"><tr><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico/Description" ><img border="0" width="600" src="https://static.igem.org/mediawiki/2009/3/3e/Description_a.png" id="des" onmouseover="mouseOver_des()" onmouseout="mouseOut_des()" align="center"></a></tr> |
| - | -Sadly we have no news, but stay in touch!!!! | + | <br><br> |
| - | | + | <tr><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico/Parts" ><img border="0" width="600" src="https://static.igem.org/mediawiki/2009/a/a4/Parts_a.png" id="parts" onmouseover="mouseOver_parts()" onmouseout="mouseOut_parts()" align="center"></a></tr> |
| - | ==Sponsors== | + | <br><br> |
| - | <html> | + | <tr><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico/Resources" ><img border="0" width="600" src="https://static.igem.org/mediawiki/2009/9/93/Resources_a.png" id="res" onmouseover="mouseOver_res()" onmouseout="mouseOut_res()" align="center"></a> |
| - | <style> | + | </tr> |
| - | a:link { color: #659D32; text-decoration: none} | + | <br><br> |
| - | a:visited { color:#659D32; text-decoration: none}
| + | <tr><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico/Modelling" ><img border="0" width="600" src="https://static.igem.org/mediawiki/2009/8/83/Modelling_a.png" id="mod" onmouseover="mouseOver_mod()" onmouseout="mouseOut_mod()" align="center"></a> |
| - | a:hover { color:#f29400; text-decoration: none} | + | </tr> |
| - | a:active { color:#f29400; text-decoration: none} | + | </body> |
| - | </style> | + | |
| | </html> | | </html> |
| - | [[image:Ccg_logo.png|center|100px|https://static.igem.org/mediawiki/2009/7/71/Ccg_logo.png]]
| |
| - | <p style="text-align: center;">[http://www.ccg.unam.mx Centro de Ciencias Genomicas]</p>
| |
| | | | |
| - | [[image:Lcg_logo.png|center|100px|https://static.igem.org/mediawiki/2009/e/ef/Lcg_logo.png]]
| + | <!--Do not remove the first and last lines in this page!-->{{Template:LCG_bottom_Netscape}} |
| - | <p style="text-align: center;">[http://www.lcg.unam.mx Genomic Sciences Undergraduate program]</p> | + | |
| - | | + | |
| - | [[image:Unam.gif|center|100px|https://static.igem.org/mediawiki/2009/a/a1/Unam.gif]]
| + | |
| - | <p style="text-align: center;">[http://www.unam.mx/ UNAM]</p>
| + | |
| - | | + | |
| - | | + | |
| - | |}
| + | |
"