Team:Todai-Tokyo

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''We are planing 5 projects.<BR>
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1.oscillation<BR>
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2.bioclock<BR>
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3.tabacco<BR>
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4.Food<BR>
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5.Arterisclerosis<BR>
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1.We will make the oscillation by using the expression of some proteins. We haven't decided what protein we would use. But,if we could make 24 hours-oscillation ,we'd use this system to invent bioclock.<BR>
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2.Cyanobacteria has clock genes;KaiA,B,C. KaiC is phosphatized and phospharylized in cycles.The term between one phosphatization and the next is 24 hours. KaiB phosphataize KaiC. KaiA binds KaiB and inhibits the phosphataization of KaiC. We inject these genes into E.coli and let E.coli express interesting proteins every day. If something,that wakes humans, expressed, we could use it as an alarm clock.<BR>
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3.If you broken your promise and smoked, your mouth would begin to smell.We are growing E>coli or bacterias which express the enzyme that reacts Nicotine and catalyzes a smelling substract.<BR>
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4.We are making food which has additional nutritions.Without adding sugar,Bread becomes sweet by enzymes of bread yeast. Food has more vitamins. etc.<BR>
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5.Arteriosclerosis is caused by LDL cholesterols. So, we are growing E.coli which express LDL cholesterol receptor and inhibits the absorption of LDLcholesterols in the blood vassel.<BR>
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|align="center"|[[Team:Todai-Tokyo | Team Example]]
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!align="center"|[[Team:Todai-Tokyo|Home]]
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!align="center"|[[Team:Todai-Tokyo/Team|The Team]]
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!align="center"|[[Team:Todai-Tokyo/Project|The Project]]
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!align="center"|[[Team:Todai-Tokyo/Parts|Parts Submitted to the Registry]]
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!align="center"|[[Team:Todai-Tokyo/Modeling|Modeling]]
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!align="center"|[[Team:Todai-Tokyo/Notebook|Notebook]]
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<font face = "Helvetica" size = 6><BR>THEME</font>
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<font size = 5 color = "#915707"><BR>"Prevention of lifestyle diseases using synthetic living systems"<BR><BR></font>
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&nbsp;Lifestyle diseases, diseases caused by unhealthy living habits,
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comprise one of the major problems in modern society, especially as they may lead
 +
to fatal heart problems or even cancer. However, preventing or curing these
 +
diseases is extremely difficult at present.<BR>
 +
&nbsp;Our team, Todai-Tokyo, has been tackling treatment of lifestyle
 +
diseases such as hypercholesterolemia, diabetes, circadian rhythm dysfunction, and
 +
bad smoking habits by using synthetic living systems, utilizing their
 +
ability to incorporate complex logic functions and dispensability of external
 +
control once in operation. To do this, we aim to create the following:  cells
 +
that ingest cholesterol to decrease blood cholesterol levels, healthy low
 +
calorie breads, a system in which periodic gen
 +
e expression is controlled, and bacteria that encourage smokers to quit
 +
smoking, respectively. <BR>
 +
&nbsp;By applying similar synthetic biology  methodologies to these,
 +
prevention of numerous lifestyle-related diseases may become reality, serving as a
 +
first step towards their eradication.
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<BR>
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    <div id="right_side">
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    <font size ="4" face="Helvetica" color="#915707" >sponsored by<BR><BR></font>
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    <a href="http://www.hitachi-hitec.com/global/index.html"><img src="https://static.igem.org/mediawiki/2009/8/87/Todai_hitachihitec.gif" alt="" width="180" length="50" id="photo"/></a>
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    <a href="http://www.nisr.or.jp/index.htm"><img src="https://static.igem.org/mediawiki/2009/8/81/Todai_nodalogo.jpg" alt="" width="180" length="100" id="photo"/></a>
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</div>
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    <div class="article01">
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<font face = "Helvetica" size = 6>1.</font><font size = 5 color = "#915707">"Imagine there's no smoker"</font><BR>
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  A large part of the world is bitter towards the act of smoking. However, many people like smoking or cannot quit. You might be one of such person. As a solution, what if a noxious smell is emitted from your mouth if you smoke by braking the "non-smoking promise"?? Your breath will stink and all the people around you: professors, friends, family members, and even your boy/girl friend will leave you. You will have not choice but to live in isolation....
 +
We are growing <i>E.coli</i> that express an enzyme that reacts to Dioxine and catalyzes the production of a smelly substance.<BR><a href="https://2009.igem.org/Team:Todai-Tokyo/Project#Tobacco">>>in detail</a><BR>
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</div>
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    <div class="article02"><font face = "Helvetica" size = 6>2.</font><font size = 5 color = "#915707">"DON'T BEAR OFF, EAT WHAT YOU WANT!"</font><BR>
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  Yes, everybody wants to eat what they want. Many like beaf　steak, fried chicken, pork cutlets, hot dogs, hamburgers, fatty foods, and so on. One only has to imagine such foods to start drooling with saliva. However, eating too much fatty food can be dangerous for the body. It is very unhealthy. Such foods (that we like? or does the food like us? I wonder) contain a lot of LDL cholesterol. LDL cholesterol can be the cause of many diseases. In the end, we eat what we want! So, one of our projects will make this desire come true. We here suggest a new way to prevent one of the diseases LDL cholesterol causes.
 +
Arteriosclerosis is caused by LDL cholesterols. So, we are growing S.cerevisiae which express LDL cholesterol receptor and inhibits the absorption of LDLcholesterol in the blood vessel.
 +
<BR><a href="https://2009.igem.org/Team:Todai-Tokyo/Project#Arterisclerosis">>>in detail</a><BR>
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</div>
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<div class="article03">
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<font  face = "Helvetica"  size = 6>3.</font><font size = 5 color = "#915707">"Nothing's gonna stop me from sleeping!?"</font><BR>
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You may need to get up early in the morning everyday. Perhaps you may be suffering from sleeping disorders. You sometimes oversleep and sometimes get up too early. Normal alarm clocks are, as we all know, outside of your body, so you can stop the alarm easily and then you continue with your good dreams...you may be in the middle of consuming a delicious chocolate bar or you may be in the process of winning the lottery...however, you get up only to realize that you have overslept. But what if the alarm clock was in your body? Try your luck in stopping this one!
 +
Our project is to create such a bioclock, able to be used inside the human body. We will produce <i>E.coli</i> that oscillates by expressing GFP cyclically. The oscillation is induced by UV light and stops at the pre-programmed time. <a href="https://2009.igem.org/Team:Todai-Tokyo/Project#Bioclock">>>in detail</a>
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</div>
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<div class="article04">
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<font face = "Helvetica"  size = 6>4.</font><font size = 5 color = "#915707">"If they have no bread,let them eat bread without sugar"</font><BR>
 +
In Contrast to when Marie Antoinette said these words, the price of bread is not a major problem in the modern world.  Bread can be eaten pretty much whenever people want to. Many people all over the world like bread (of course including us Japanese). However, making bread requires sugar,and sugar may cause the fearful disease "diabetes!"...So, we will be all happier if we can eat bread without the worry of diabetes.
 +
We are making food containing additional nutrition. Without adding sugar, bread becomes sweet with the help of enzymes. <BR><a href="https://2009.igem.org/Team:Todai-Tokyo/Project#Bread">>>in detail</a><BR>
 +
</div>
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</body>
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</html>

Latest revision as of 02:38, 22 October 2009

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Home The Team The Project Parts Submitted to the Registry Modeling Notebook Protocols Ethics



CSS


THEME
"Prevention of lifestyle diseases using synthetic living systems"

  Lifestyle diseases, diseases caused by unhealthy living habits, comprise one of the major problems in modern society, especially as they may lead to fatal heart problems or even cancer. However, preventing or curing these diseases is extremely difficult at present.
 Our team, Todai-Tokyo, has been tackling treatment of lifestyle diseases such as hypercholesterolemia, diabetes, circadian rhythm dysfunction, and bad smoking habits by using synthetic living systems, utilizing their ability to incorporate complex logic functions and dispensability of external control once in operation. To do this, we aim to create the following: cells that ingest cholesterol to decrease blood cholesterol levels, healthy low calorie breads, a system in which periodic gen e expression is controlled, and bacteria that encourage smokers to quit smoking, respectively.
 By applying similar synthetic biology methodologies to these, prevention of numerous lifestyle-related diseases may become reality, serving as a first step towards their eradication.
sponsored by
1."Imagine there's no smoker"
A large part of the world is bitter towards the act of smoking. However, many people like smoking or cannot quit. You might be one of such person. As a solution, what if a noxious smell is emitted from your mouth if you smoke by braking the "non-smoking promise"?? Your breath will stink and all the people around you: professors, friends, family members, and even your boy/girl friend will leave you. You will have not choice but to live in isolation.... We are growing E.coli that express an enzyme that reacts to Dioxine and catalyzes the production of a smelly substance.
>>in detail
2."DON'T BEAR OFF, EAT WHAT YOU WANT!"
Yes, everybody wants to eat what they want. Many like beaf　steak, fried chicken, pork cutlets, hot dogs, hamburgers, fatty foods, and so on. One only has to imagine such foods to start drooling with saliva. However, eating too much fatty food can be dangerous for the body. It is very unhealthy. Such foods (that we like? or does the food like us? I wonder) contain a lot of LDL cholesterol. LDL cholesterol can be the cause of many diseases. In the end, we eat what we want! So, one of our projects will make this desire come true. We here suggest a new way to prevent one of the diseases LDL cholesterol causes. Arteriosclerosis is caused by LDL cholesterols. So, we are growing S.cerevisiae which express LDL cholesterol receptor and inhibits the absorption of LDLcholesterol in the blood vessel.
>>in detail
3."Nothing's gonna stop me from sleeping!?"
You may need to get up early in the morning everyday. Perhaps you may be suffering from sleeping disorders. You sometimes oversleep and sometimes get up too early. Normal alarm clocks are, as we all know, outside of your body, so you can stop the alarm easily and then you continue with your good dreams...you may be in the middle of consuming a delicious chocolate bar or you may be in the process of winning the lottery...however, you get up only to realize that you have overslept. But what if the alarm clock was in your body? Try your luck in stopping this one! Our project is to create such a bioclock, able to be used inside the human body. We will produce E.coli that oscillates by expressing GFP cyclically. The oscillation is induced by UV light and stops at the pre-programmed time. >>in detail
4."If they have no bread,let them eat bread without sugar"
In Contrast to when Marie Antoinette said these words, the price of bread is not a major problem in the modern world. Bread can be eaten pretty much whenever people want to. Many people all over the world like bread (of course including us Japanese). However, making bread requires sugar,and sugar may cause the fearful disease "diabetes!"...So, we will be all happier if we can eat bread without the worry of diabetes. We are making food containing additional nutrition. Without adding sugar, bread becomes sweet with the help of enzymes.
>>in detail

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