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Team:Illinois/Modeling
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sRNA regulation is a post-transcription regulation mechanism in which the mRNA transcript is degraded before it can be translated or preventing further translation. Traditionally regulation via sRNA is faster acting than transcription factors because there is no delay due to translation and protein folding.[[modeling_resources|[1]]] For this reason, sRNAs are often found to regulate stress and environmental responses. For example, the sRNA, SgrS regulates PtsG, coding for two protein subunits EIIB and EIIC which are involved in the glucose phosphate stress response. [[modeling_resources|[2]]] | sRNA regulation is a post-transcription regulation mechanism in which the mRNA transcript is degraded before it can be translated or preventing further translation. Traditionally regulation via sRNA is faster acting than transcription factors because there is no delay due to translation and protein folding.[[modeling_resources|[1]]] For this reason, sRNAs are often found to regulate stress and environmental responses. For example, the sRNA, SgrS regulates PtsG, coding for two protein subunits EIIB and EIIC which are involved in the glucose phosphate stress response. [[modeling_resources|[2]]] | ||
| - | The rate for protein translation after sRNA regulation is governed by the following simple differential equations. | + | The rate for protein translation after sRNA regulation is governed by the following simple differential equations. N is the number of particles, g is the growth rate, and d is the rate of decay or half life of a particle. Subtext s, m, and p, denotes sRNA, mRNA, and protein respectively. |
N<sub>s</sub> : Number of sRNA transcripts | N<sub>s</sub> : Number of sRNA transcripts | ||
Revision as of 01:24, 19 June 2009
Modeling
sRNA regulation is a post-transcription regulation mechanism in which the mRNA transcript is degraded before it can be translated or preventing further translation. Traditionally regulation via sRNA is faster acting than transcription factors because there is no delay due to translation and protein folding.[1] For this reason, sRNAs are often found to regulate stress and environmental responses. For example, the sRNA, SgrS regulates PtsG, coding for two protein subunits EIIB and EIIC which are involved in the glucose phosphate stress response. [2]
The rate for protein translation after sRNA regulation is governed by the following simple differential equations. N is the number of particles, g is the growth rate, and d is the rate of decay or half life of a particle. Subtext s, m, and p, denotes sRNA, mRNA, and protein respectively.
Ns : Number of sRNA transcripts gs : rate of sRNA transcription
Nm : Number of mRNA transcripts gm : rate of mRNA transcription
Np : Number of expressed protein gp : rate of protein translation
Questions about our Wiki page? Please email Dave Korenchan at korench1@illinois.edu.
