Team:Stanford/NotebookPage/18 August 2009

Events

• 9am meeting w/ Grad Student
  • Anusuya w/ IBD and Immune System
    • Not so much Immunology....
    • Emphasize work w/ Il-10 treatment= PRECEDENT
    • Need slide w/ differentiation
    • Too many slides
    • Symptoms- mention somewhere else but don't necessarily need its own slide
      • Is video necessary?
    • Emphasize why our therapy is BETTER
      • Awesomeness on 1 slide - update advantages slide to compare to current therapy
      • Table? Larger font?
    • Answer question more clearly about why we need device 2
  • Suzie's Slides w/ Constructions
    • Slide 1 - colored lines and provide key
    • Slide 2 - mention vBOL
    • Slide 3 - ask about sequences leading to protein- is it correct? Add arrows
      • Graph Larger
    • Slide 4- Easiest to understand and just label important parts..weak constitutive beta carotene?? OR not?
    • Slide 5 - metadata?
    • Slie 6- rest.... revise for device 2... const export system?
  • Mark and lab update...
    • Cultures of parts... mini-prep and pcr w/ new primers...

• 5:30 meeting w/ Clinician
  • Update From Meeting with IBD Specialist Dr. Shamita Shah
    • Good News
      • Fully supportive of the concept
      • Understands importance of and our reasoning behind both devices
      • Supports probiotic research
      • Enthusiastic for future implications of this device as a “treatment/diagnostic tool”
      • Willing to share her own slides on IBD and give 20 presentation on her current knowledge
        • She has great statistics and can help us frame our device to tailor to a specific target audience
    • Next Steps
      • Decide what “phase” of IBD we want to target
      • Early diagnostic… difficult to distinguish between UC and Crohn’s, but certainly useful
      • Complementary treatment: use as another “tool” for clinicians
      • Post-treatment diagnostic to prevent recurrence…
      • Dr. Shah sees this as the most promising and necessary right now w/ regards to treatment
      • No previous probiotic research in this field
      • Many cases lead to recurrence- and patients need annual colonic scopes
    • Meet w/ Dr. Shah again early September
    • Challenges
      • We need numbers…
      • The “ratio” needs to be known or better understood and Dr. Shah doesn’t collect these numbers
      • When/how will the device be “triggered” with regards to these numbers?
      • Switch bacterial strain to be more sustainable in the small intestine?