Team:Virginia/Idea

From 2009.igem.org

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[[Image:Idea.png|200px]]
[[Image:Idea.png|200px]]
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=Biosequestration=
(Intro about biosequestration)
(Intro about biosequestration)
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=Storage and binding=
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Surveying evolved strategies for arsenic detoxification in bacteria shows that the most common mechanisms involve the efflux of arsenic ions. If we're trying to biosequester arsenic then efflux mechanisms will work counter to our goal. However, storage of free arsenic ions in a cell will be toxic. Therefore a successful arsenic sponge needs to incorporate both a mechanism to prevent efflux as well as binding arsenic in a non-toxic form.
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Surveying evolved strategies for arsenic detoxification in bacteria shows that the most common mechanisms involve the efflux of arsenic ions. Our goal is to sequester arsenic, therefore to use a microbial chassis we must inhibit its efflux mechanism. However, storage of free arsenic ions in a cell will be toxic. Therefore a successful arsenic sponge needs to also incorporate a binding mechanism that allows the cell to accumulate significant amounts of arsenic.  
''Escherichia coli'' uses the [http://ecoliwiki.net/colipedia/index.php/arsB ArsB] ion transporter
''Escherichia coli'' uses the [http://ecoliwiki.net/colipedia/index.php/arsB ArsB] ion transporter

Revision as of 16:03, 21 October 2009

edit

Idea.png

Biosequestration

(Intro about biosequestration)

Storage and binding

Surveying evolved strategies for arsenic detoxification in bacteria shows that the most common mechanisms involve the efflux of arsenic ions. Our goal is to sequester arsenic, therefore to use a microbial chassis we must inhibit its efflux mechanism. However, storage of free arsenic ions in a cell will be toxic. Therefore a successful arsenic sponge needs to also incorporate a binding mechanism that allows the cell to accumulate significant amounts of arsenic.

Escherichia coli uses the [http://ecoliwiki.net/colipedia/index.php/arsB ArsB] ion transporter