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Team:SupBiotech-Paris
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| - | + | Welcome foreigner, | |
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| + | Gene therapy issue is the non-specificity of cells population markers in organism. In contrast, it is highly specific in a tissue. | ||
| + | Our project is a vectorization system using both bacteria and virus-like, to improve the targeting. We chose mycobacterium, a microorganism with high tropism for specific tissues, and a synthetic Lambda phage able to infect eukaryotic cells. | ||
| + | First, to target tissue, we use mycobacterium, and then to target the cell population, we use the synthetic lambda phage. | ||
| + | But, phage production should be control to avoid the bacteria lysis and so the destruction of the first vector when it is outside of its targeted tissue. So, we designed an inductive system by tissue specific recognition. | ||
| + | In the bacteria targeted tissue, the inductive system induces the phage production and bacteria lysis. Released phages can infect the target cells. | ||
| + | The use of the double targeting vector will amplify the specificity of the gene therapy and allow targeting a precise cell population. | ||
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| + | Bye! | ||
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|[[Image:Team.png|right|frame|Your team picture]] | |[[Image:Team.png|right|frame|Your team picture]] | ||
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Revision as of 18:17, 30 July 2009
| You can write a background of your team here. Give us a background of your team, the members, etc. Or tell us
more about something of your choosing. |  |
|
Welcome foreigner, Gene therapy issue is the non-specificity of cells population markers in organism. In contrast, it is highly specific in a tissue. Our project is a vectorization system using both bacteria and virus-like, to improve the targeting. We chose mycobacterium, a microorganism with high tropism for specific tissues, and a synthetic Lambda phage able to infect eukaryotic cells. First, to target tissue, we use mycobacterium, and then to target the cell population, we use the synthetic lambda phage. But, phage production should be control to avoid the bacteria lysis and so the destruction of the first vector when it is outside of its targeted tissue. So, we designed an inductive system by tissue specific recognition. In the bacteria targeted tissue, the inductive system induces the phage production and bacteria lysis. Released phages can infect the target cells. The use of the double targeting vector will amplify the specificity of the gene therapy and allow targeting a precise cell population. Bye! |  Your team picture |
| Team Example |
| Home | The Team | The Project | Parts Submitted to the Registry | Modeling | Notebook | Sponsor |
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(Or you can choose different headings. But you must have a team page, a project page, and a notebook page.)
