Team:LCG-UNAM-Mexico/Project

From 2009.igem.org

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  Script-Free 3-Level Menu 1.3.4
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  www.CesarDaniel.info/Tech/ScriptFree3LevelMenu.html
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  ...............................................................................................
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  Sections
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                Keep it sync with the drop-down menu width.
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div.MenuBar ul li:hover ul.DropDownMenu li:hover ul.SideMenu li a,
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                        Hidden (* html) from non-IE browsers. */
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* html div.MenuBar ul li a {
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                  Breaks O9.
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                  Hidden (* html) from non-IE browsers. */
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* html div.MenuBar ul li table,
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* html div.MenuBar ul li table td {
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                Hidden (* html) from non-IE browsers. */
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/*------------------------------------------------------------------------------- Default Colors */
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  background-color: #87C988; /* Drop-down menu unselected items.
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                            Sets the drop-down menu "effective background" color. */
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div.MenuBar ul li:hover ul.DropDownMenu li:hover ul.SideMenu,
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          <div class="MenuBar" id="LCG">
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            <ul>
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              <li>
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                <a href="https://2009.igem.org/Team:LCG-UNAM-Mexico" onMouseOver="window.status= 'Click here to return Home'; return true;">Home
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                <!--[if gt IE 6]><!--></a><!--<![endif]-->
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                <!--[if lt IE 7]><table border="0" cellpadding="0" cellspacing="0"><tr><td><![endif]-->
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                <!--[if lte IE 6]></td></tr></table></a><![endif]-->
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              </li>
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              <li>
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                <a href="https://2009.igem.org/Team:LCG-UNAM-Mexico/Record">Record
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                <!--[if gt IE 6]><!--></a><!--<![endif]-->
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                <!--[if lt IE 7]><table border="0" cellpadding="0" cellspacing="0"><tr><td><![endif]-->
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  </li>
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              <li>
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                <a href="https://2009.igem.org/Team:LCG-UNAM-Mexico/Project">Project</a>
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                <ul class="DropDownMenu" id="Ddm1">
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  <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico/Parts"><span><span>Parts</span></span></a></li>
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                  <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico/Resources"><span><span>Resources</span></span></a></li>
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                  <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico/Description"><span><span>Description</span>>></span></a>
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                    <!--[if lt IE 7]><table border="0" cellpadding="0" cellspacing="0"><tr><td><![endif]-->
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                    <ul class="SideMenu" id="Sm11">
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                      <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico/Description"><span><span>Design</span></span></a></li>
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  <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico/Description"><span><span>Delivery</span></span></a></li>
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  <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico/Description"><span><span>Defense</span></span></a></li>
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                    <!--[if lte IE 6]></td></tr></table></a><![endif]-->
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                </ul>
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      </li>
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              <li>
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                <a href="https://2009.igem.org/Team:LCG-UNAM-Mexico/Team">Team</a>
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<ul class="DropDownMenu" id="Ddm2">
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                  <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico/Team"><span><span>Aknowledgments</span></span></a></li>
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                  <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico/Team"><span><span>Collaborations</span></span></a></li>
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                  <li><a href="https://2009.igem.org/Team:LCG-UNAM-Mexico/Team"><span><span>Sponsors</span></span></a></li>
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  </li>
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          <!-- End of Script-Free 3-Level Menu 1.3 Example -->
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</body>
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</html>
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{|
{|
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<!--Do not remove the first and last lines in this page!-->{{Template:LCG_bottom_Netscape}}
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<html>
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<header>
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<script language="JavaScript">
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</script>
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</header>
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<style>
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#bodyContent { padding: 10px auto; width: 1000px; margin: auto; clear: none; }
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a:link { color: #659D32; text-decoration: none}
+
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a:visited { color:#659D32; text-decoration: none}
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a:hover { color:#f29400; text-decoration: none}
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a:active { color:#f29400; text-decoration: none}
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</style>
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<body>
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<table border="0" align="center" width="900" cellpadding="50"><tr><th><a href="#" onCLick="window.history.go(-1); return false;"><img border="0"  src="https://static.igem.org/mediawiki/2009/d/d5/Flecha_left.png" id="left" onmouseover="mouseOver_left()" onmouseout="mouseOut_left()"></a></th><th><a href="https://2009.igem.org/wiki/index.php?title=Team:LCG-UNAM-Mexico/intento1"><img border="0"  src="https://static.igem.org/mediawiki/2009/4/41/Home_LCG_UNAM.png" id="home" onmouseover="mouseOver_home()" onmouseout="mouseOut_home()"></a></th><th><a href="#" onCLick="window.history.go(1); return false;"><img border="0" src="https://static.igem.org/mediawiki/2009/a/af/Flecha_right.png" id="right" onmouseover="mouseOver_right()" onmouseout="mouseOut_right()"></a></th></tr></table>
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Revision as of 22:15, 13 October 2009


The Project

Bacteriophage infection represents a common matter in science and industry. We propose to contend with such infections at a population level by triggering a defense system delivered by an engineered version of the satellite phage P4. This phage will be produced into an E. coli strain which harbors some genes from the helper phage P2 that are used for complementing and completing P4 life cycle, hence creating a production line of our version of P4.

This will enable phage production and subsequent delivery of the defense system into wild-type E. coli and possibly other bacterial host strains.

The defense will consist of DNA and RNA degradation by toxins which will be activated by T3 or T7 RNA-Polymerases and transcribed fast enough to stop phage assembly and scattering in the environment.

Moreover, the system includes the spread of a quorum sensing signal, hence "warning" the population to prepare against further T3 or T7 infection.

We will implement a stochastic population model to simulate the infection processes and quantify the efficiency of our system.






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