The Project
With more and easier access to high-calorie
foods the worldwide prevalence of obesity has
been on the rise in the past quarter century. In
Canada alone, the average rate of obesity has
doubled from 1979 to 2004, and approximately
23% of Canadian adults are obese (As estimated
by Statistics Canada). Obesity is typically
associated with many adverse health conditions
and puts an enormous strain on the public
healthcare system. Our goal is to engineer a
strain of Lacobacillus to express the enzymes
required for the synthesis of cellulose from glucose
in an attempt to reduce the caloric intake
of obese individuals. Cellulose is a polymer of
linked D-glucose units that cannot be digested
by humans. Lactobacillus is a strain of bacteria,
which is commonly used to make yogurt,
cheese, beer and other fermented foods, and
is in fact part of the natural human gut fl ora.
The idea would be to have an obese individual
ingest yogurt containing our engineered strain
of bacteria as a probiotic. That way after they
have consumed their meal, a portion of the
glucose from the meal would be converted into
cellulose in the intestines, effectively reducing
their caloric intake.
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