Abstract

For iGEM 2009, the Imperial College London team is proud to present The E.ncapsulator. We propose a versatile manufacture and delivery platform by which therapeutics can be reliably targeted to the intestine. The E.ncapsulator represents a novel approach to drug delivery that bypasses the need for expensive purification, packaging and storage treatments.

Through the addition and modification of genetic pathways, our E.coli chassis progresses through a series of defined stages culminating in the production of a safe, inanimate pill. This sequential process involves drug production, protective encapsulation and genome deletion. The transition through each of these stages has been designed with industrial production in mind, using induction by both media and temperature.

The E.ncapsulator’s versatility is demonstrated by its ability to deliver any biologically synthesisable compound. The advantages that The E.ncapsulator offers over conventional pill manufacture makes it an attractive candidate for commercial development and additionally demonstrates the huge potential of synthetic biology in the field of manufacturing.

The full project description can be found here.

Project Overview

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