Team:METU-Gene/Gelatin Sponge

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It is believed that, epidermal growth factor (EGF) stimulates the growth of keratinocytes in vivo, and therefore plays an important role in the process of wound healing that depends on mitosis and migration of keratinocytes. Rhinewald and Green showed, in vitro that in the presence of growth factors, higher percentage of cells leave the resting state, enter and remain in the mitotic cycle [23]. Assuming a similar e!ect of EGF on epidermal cells in vivo, the primary mechanism of enhanced wound healing is most likely due to increased proliferation of epidermal cells.

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Mitogenic e!ect of EGF requires continuous exposure of target cells to EGF for a minimum 6}12 h.The stimulation of wound healing by EGF has been con"rmed by Laato et al. as growth of granulation tissue in sponge implants used as inductive matrices [33].Buckley et al. reported that sustained release of EGF from subcutaneous pellets accelerated process of wound repair in rats, whereas daily injections of EGF were much less e!ective [30].

October 15, 2009

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