Events in Wound Dressing

RED EVENT : Introduction of Oxygen into wound dressing is performed via pores of polyurethane. Oxygen induction activates Human epidermal growth factor synthesis in E. Coli colony 1.
PURPLE EVENT : hEGF proteins fuse the second polyurethane layer and reach the gelation sponge. While gelatin sponge is biologically degraded on wounds, Hegf proteins reach the wound and contribute to proliferation of cells by accelerating the speed of cell divisions. Meanwhile, AI-2, the quorum sensing molecules of colony 1, activates synthesis of Human keratinocyte growth factor(hKGF).
LIGHT GREEN EVENT: The synthesis of hKGF is performed by the effects of AI-2 on colony-2. Human keratinocyte growth factor fuses the second polyurethane layer and follows the same pathway of hEGF proteins which causes the migration of cells in the wounds. At the same time, Aı-2 proteins of colony-1 starts the synthesis of AHL(homoserine lactone).
BLACK EVENT: The synthesis of homoserine lactone (AHL) is provided by colony-2 . AHL proteins fuse with available LuxR proteins and activate the lysis pathways of both colony -1 and colony-2.

GRAY EVENT: Biological degradation of gelatin sponge inhibits the protease activity in wounds. Inhibition of proteases provide prolonged activity of hEGF, hKGF and granulysin proteins.
DARK GREEN EVENT: Biodegradable gelatin sponge contains granulysin antimicrobial proteins. While the gelatin sponge is degraded, granulysin proteins spread to the wound and kill both gram positive and gram negative bacteria. The other advantage of granulysin protein is being antitumor factor. Granulysin protein fastens the inflammatory phase of wound healing.