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Team:Todai-Tokyo/Project
From 2009.igem.org
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Contents |
Overall project
We are planing 4 projects.
1.bioclock
2.tobacco
3.Bread
4.Arterisclerosis
1.We will produce E.coli that can let me know what time it is now by expressing Fluorescent Protein.
2.If you broken your promise and smoked, your mouth would begin to smell.We are growing E>coli or bacterias which express the enzyme that reacts Nicotine and catalyzes a smelling substract.
3.We are making food which has additional nutritions.Without adding sugar,Bread becomes sweet by enzymes of bread yeast. Food has more vitamins. etc.
4.Arteriosclerosis is caused by LDL cholesterols. So, we are growing S.cerevisiae which express LDL cholesterol receptor and inhibits the absorption of LDLcholesterols in the blood vassel.
Project Details
bioclock
tobacco
We will make bacteria to help those who want to quit smoking to attain their goal. In order to achieve this, we are constructing the bacteria that begin to smell when exposed to smoke.
The way to use these bacteria is very simple. 1. At first, we get those who have to break their habit of smoking to take these bacteria. 2. And then, if they break the ban and smoke, they will be worried by strong smell like a cheese or dirty socks. 3. Thereafter they will never smoke anymore.
Next, I'll explain the mechanism of this bacteria. 1. First, dioxin in smoke reacts the activator protein Ahr. 2. Then, Ahr and protein ARNT binds the enhancer XRE, and yqiT is expressed.
*YqiT codes Leucine dehydrogenase descended from Bacillus subtilis.
*The Leucine dehydrogenase makes isovaleric acid from Leucine.
*Isovaleric acid is a major component of the cause of unpleasant foot smell.
This is our project. These bacteria can be used for other kind of sensors by changing promoter.
