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Control model

Because we want to optimize the design of the feedback loop in our system, we developed a more abstract block scheme of the bacteria. It shows each component as a block performing a specific task. The diagram is used to develop some theories about the performance of the feedback loop.

Because the controller has to be implemented in 'biological technology', we choose the simplest possible design of controller, the proportional controller. The gain in the feedback loop can be adjusted by the use of low/high copy plasmids for the genes involved in the transduction of the signal in the feedback loop.

Block model of the system with proportional controller (Simulink)

Biological implications

Because the controller has to be implemented in 'biological technology', we choose the simplest possible design of controller, the proportional controller. The gain in the feedback loop can be adjusted by the use of low/high copy plasmids for the genes involved in the transduction of the signal in the feedback loop.

Simulations

In order to check the set-up of the model and to estimate the behaviour of the real bacterium, we performed a number of simulations.