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Team:Alberta/References/Publications/Shear unzipping of DNA
From 2009.igem.org
Buddhapriya Chakrabarti and David R. Nelson
J. Phys. Chem. B, 2009, 113 (12), pp 3831–3836
Abstract: We study theoretically the mechanical failure of a simple model of double-stranded DNA under an applied shear. Starting from a more microscopic Hamiltonian that describes a sheared DNA, we arrive at a nonlinear generalization of a ladder model of shear unzipping proposed earlier by deGennes [de Gennes, P. G. C. R. Acad. Sci., Ser. IV: Phys., Astrophys. 2001, 1505]. Using this model and a combination of analytical and numerical methods, we study the DNA “unzipping” transition when the shearing force exceeds a critical threshold at zero temperature. We also explore the effects of sequence heterogeneity and finite temperature
and discuss possible applications to determine the strength of colloidal nanoparticle assemblies functionalized by DNA.
Link: Journal of Physical Chemistry
