Team:EPF-Lausanne/Modeling

From 2009.igem.org

(Difference between revisions)
Line 14: Line 14:
               
               
-
<a href="https://2009.igem.org/Team:EPF-Lausanne/Parts" onMouseOver="document.MyImage6.src='https://static.igem.org/mediawiki/2009/thumb/0/0c/Analysis_nb.jpg/150px-Analysis_nb.jpg';" onMouseOut="document.MyImage6.src='https://static.igem.org/mediawiki/2009/thumb/8/84/Analysis.jpg/150px-Analysis.jpg';">
+
<a href="https://2009.igem.org/Team:EPF-Lausanne/Analysis" onMouseOver="document.MyImage6.src='https://static.igem.org/mediawiki/2009/thumb/0/0c/Analysis_nb.jpg/150px-Analysis_nb.jpg';" onMouseOut="document.MyImage6.src='https://static.igem.org/mediawiki/2009/thumb/8/84/Analysis.jpg/150px-Analysis.jpg';">
<img src="https://static.igem.org/mediawiki/2009/thumb/8/84/Analysis.jpg/150px-Analysis.jpg" name="MyImage6"></a></center>
<img src="https://static.igem.org/mediawiki/2009/thumb/8/84/Analysis.jpg/150px-Analysis.jpg" name="MyImage6"></a></center>
</html>
</html>

Revision as of 12:39, 30 July 2009

Contents

                               


Modeling



To do

- Model allosteric interactions between LOVTAP & TrpR
What will be done:
- Model of LOVTAP in dark phase
- Model of LOVTAP in light phase
- Characterize how the J-alpha helix changes
- Model structural changes that enhance the switch feature of LOVTAP e.g. in dark phase: really weak interaction between LOVTAP and the corresponding DNA sequence, in light phase: strong binding of LOVTAP on DNA.
- Between Light state and Dark State
- RMS between light state and dark state
- length between the two arms N C
- only cytochrome with interactions in light state and dark state


To envisage


- Molecular mutational assay