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Team:EPF-Lausanne/Modeling
From 2009.igem.org
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| + | ==Protein domain of interest== | ||
| + | LOVTAP | ||
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| + | ==Goal== | ||
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| + | ==Starting material== | ||
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| + | ==Molecular dynamics== | ||
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| + | ==Steps== | ||
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| + | ==References== | ||
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| + | ==Analysis methodology== | ||
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| + | ==Results== | ||
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==To do== | ==To do== | ||
Revision as of 07:12, 21 September 2009
Contents |
Protein domain of interest
LOVTAP
Goal
Starting material
Molecular dynamics
Steps
References
Analysis methodology
Results
To do
- - Model allosteric interactions between LOVTAP & TrpR
- What will be done:
- - Model of LOVTAP in dark phase
- - Model of LOVTAP in light phase
- - Characterize how the J-alpha helix changes
- - Model structural changes that enhance the switch feature of LOVTAP e.g. in dark phase: really weak interaction between LOVTAP and the corresponding DNA sequence, in light phase: strong binding of LOVTAP on DNA.
- - Between Light state and Dark State
- - RMS between light state and dark state
- - length between the two arms N C
- - only cytochrome with interactions in light state and dark state
To envisage
- Molecular mutational assay
