Team:LCG-UNAM-Mexico

From 2009.igem.org

(Difference between revisions)
Line 1: Line 1:
-
<!-- *** What falls between these lines is the Alert Box!  You can remove it from your pages once you have read and understood the alert
 
-
 
<html>
<html>
Line 169: Line 167:
</body>
</body>
</html>
</html>
-
</html>
 
-
 
-
-->
 
-
 
-
 
-
 
-
{|align="justify"
 
-
<html>
 
-
<br><hr>
 
-
<H3>About Us</h3><br>
 
-
Hi, welcome to our site!  We are students from the undergraduate program in Genomic Sciences which is part of the National Autonomous University of Mexico. We are working on the official version of the wiki. Here you will find advances and general information about our project.<br> Here are some links:<br><br><a href='www.lcg.unam.mx'>LCG web site</a><br><a href='www.ccg.unam.mx'>Center For Genomic Sciences</a><br><a href='www.unam.mx'>UNAM</a><br>
 
-
 
-
 
-
</html>
 
-
 
-
|-
 
-
|
 
-
<html>
 
-
<br><hr>
 
-
<h3>Our Project</h3>
 
-
<hr>
 
-
Bacteriophage infection represents a major problem in the industry and
 
-
research fields. The idea of being able to contend at a population
 
-
level with such infections is the main motivation for the development of our
 
-
project. We plan to modify an Escherichia coli phage in order to deliver
 
-
genetic
 
-
material codifying a construction in defense against other phages
 
-
taking advantage of some of the properties they have.
 
-
The purpose of this construction is that a bacterial population can
 
-
manage to fight back the spreading of some phage by triggering on
 
-
a cellular death response when a cell encounters an
 
-
specific component of the phage. Such response will be faster than the
 
-
formation process of viral particles preventing the death of the bacterial
 
-
population. This population resistance can
 
-
be seen as a sort of "vaccine" that will hold back the process of
 
-
infection.
 
-
 
-
The design of the delivery system includes the use the P4 phage and
 
-
its auxiliary genes present in the P2 helper phage. In the case of the
 
-
"vaccine" construct, the cellular death response will be induced by
 
-
the presence of T3 or T7 RNA polymerases which will also turn on the
 
-
transcription of toxines used for the
 
-
degradation of DNA and RNA to stop the phage´s genetic material from
 
-
assembling and scattering in the environment. Furthermore, we will
 
-
implement a stochastic population model based on the basic properties
 
-
of the bacterial cells and the phages such as movement, reproduction,
 
-
etc., that will allow us to simulate the infection processes and
 
-
quantify the efficiency of our system. A possible extensión of the
 
-
system includes the expansion of  an AHL signal through the quorum
 
-
sensing system of Vibrio fischeri in which the population will be
 
-
"warned" to prepare against the viral infection in the presence of T3
 
-
or T7.
 
-
 
-
 
-
 
-
 
-
 
</html>
</html>

Revision as of 03:55, 14 August 2009

Untitled Document

Links:

Team Members:

-Osbaldo Rsendis
-Adrian Granados
-Laura Gomez
-Enrique Paz
-Abraham Avelar
-Soto Gutierrez
-Enrique Quintana
-Willy Garcia
-Martin del -Castillo
-Uriel Urquiza
-Arturo Velarde
-Minerva  Trejo
-Fernando Montano
-Libertad Pantoja

Check out our school:

-LCG
-Center of Genomic Sciences
-UNAM

 

 

News!

The background color on this div will only show for the length of the content. If you'd like a dividing line instead, place a border on the right side of the #mainContent div if the #mainContent div will always contain more content than the #sidebar2 div.

Donec eu mi sed turpis feugiat feugiat. Integer turpis arcu, pellentesque eget, cursus et, fermentum ut, sapien.

Main Content

Bacteriophage infection represents a major problem in industry and science. The idea of being able to contend at a population level with such infections is the main motivation of the development of our project.

We plan to modify an Escherichia coli phage in order to deliver genetic material codifying for a construction against other phages, taking advantage of some of their own properties!!! The purpose of this construction is to make a bacterial to fight back against the spreading of some phage by triggering on a cellular death response when a cell encounters a specific component of the phage. Such response will be faster than the formation process of viral particles preventing the death of the bacterial population.

This population resistance can be seen as a sort of "vaccine" that will hold back the process of infection. The design of the delivery system includes the use the P4 phage and its auxiliary genes present in the P2 helper phage. In the case of the "vaccine" construct, the cellular death response will be induced by the presence of T3 or T7 RNA polymerases which will also turn on the transcription of toxines used for the degradation of DNA and RNA to stop the phage´s genetic material from assembling and scattering in the environment.

Furthermore, we will implement a stochastic population model based on the basic properties of the bacterial cells and the phages such as movement, reproduction, etc., this will allow us to simulate the infection processes and quantify the efficiency of our system. A possible extention of the system includes the expansion of an AHL signal through the quorum sensing system of Vibrio fischeri in which the population will be "warned" to prepare against the viral infection in the presence of T3 or T7.

About us

Hi, welcome to our site! We are students from the undergraduate program in Genomic Sciences which is part of the National Autonomous University of Mexico. We are working on the official version of the wiki. Here you will find advances and general information about our project.
Here are some links:

LCG web site
Center For Genomic Sciences
UNAM



</html>

|}


Home The Team The Project Parts Submitted to the Registry Modeling Notebook
Retrieved from "http://2009.igem.org/Team:LCG-UNAM-Mexico"