Team:NTU-Singapore/Notebook/Brainstorming

From 2009.igem.org

(Difference between revisions)
(June)
(Health & medicine)
Line 24: Line 24:
** mimic the maslinic effect to the carcinogenic cells?
** mimic the maslinic effect to the carcinogenic cells?
** surface markers?
** surface markers?
 +
* trap parasites in host cells by disabling the protease
 +
** Can we remove the trap parasites?
 +
** Terminate parasites?
 +
* genetic modified bacteria that have anticoagulant properties.
 +
* eczema relief
 +
* bacteria to treat gangrene
 +
** to eat up dead tissues
 +
** bac to deliver growth factors
 +
* collagen producing bacteria
 +
* bacteria that absorbs cholesterol
 +
* constipation pill
 +
* synthesis specific growth factors
 +
* bacteria tt produce PDGF
 +
* using bacteria to breakdown blockage in blood vessels
 +
* malaria vaccine
 +
** forcibly experesses a certain gene and create a vaccine against it
 +
** to prove the concept
 +
*  cancer treatment-colon cancer(CA marker)
 +
** fusion protein to signal the expression of perforin (e coli as NKC)
 +
* streptococcus vaccine
 +
* p-falciparum gene expression stabilization ; Malaria
 +
* intestinal vaccine delivery
 +
* bac to target the larvae; Malaria
 +
*To separate Tamoxifen (possibly a chiral drug) by uptake the drugs into modified E Coli and bind it to the receptor inside the bacteria.
 +
 +
 +
== Biosensor ==
 +
 +
* biosensor that sense the present of allergen and release drugs to prevent allergenic response
 +
* Mimic allergy response-to determine allergen?
 +
* fingerprint detection
 +
* Can cells response to magnetic fields?
 +
** Bird GPS ??
 +
** magnetic field biosensor
 +
* biosensor to detect cancer
 +
 +
 +
== Environmental ==
 +
 +
* E coli to detect toxins in food and flu strain in animals.
 +
* Biomask
 +
** For absorption
 +
* create a water purifying system that recognize and trap toxic
 +
** to uptake salt and others- sea water purification
 +
* bacteria producing water for the use of photosynthesis so that plants can grow well in dry area
 +
** is it possible to construct water using certain metabolism pathway?
 +
 +
 +
== Signalling ==
 +
 +
* Multi-color display according to inputs
 +
** to improve signal inputs
 +
* DNA methylation as memory storage
 +
* suffocate the cells
 +
* baccine
 +
* To construct guiding E Coli that guide pathogenic bacteria to a region of toxin/UV light.
 +
 +
 +
==Application ==
 +
 +
* bacterial barometer
 +
* fill up crack
 +
* dust repel
 +
* microscopic spring-using spirobac
 +
* To construct a Sound sensing bacteria
 +
 +
 +
==Modeling==
 +
 +
* modeling the trend of evolution of flu viruses
 +
 +
 +
==Bioproduction==
 +
 +
* Methanol in E-coli
 +
 +

Revision as of 21:21, 21 October 2009

Experiment Timeline


Health & medicine

  • Create an insulin delivery system which response to low glucose level or time controlled release
  • Vitamin synthesis?
  • Hinder carcinogenics
    • Maslinic acid (olive skin)-tritrepenoid compound
    • Can we study anti-tumoral and apoptotic effect of this compound?
    • E coli to interfere in the carcinogenic pathways
    • mimic the maslinic effect to the carcinogenic cells?
    • surface markers?
  •  trap parasites in host cells by disabling the protease
    • Can we remove the trap parasites?
    • Terminate parasites?
  • genetic modified bacteria that have anticoagulant properties.
  • eczema relief
  • bacteria to treat gangrene
    • to eat up dead tissues
    • bac to deliver growth factors
  • collagen producing bacteria
  • bacteria that absorbs cholesterol
  • constipation pill
  • synthesis specific growth factors
  • bacteria tt produce PDGF
  • using bacteria to breakdown blockage in blood vessels
  • malaria vaccine
    •  forcibly experesses a certain gene and create a vaccine against it
    • to prove the concept
  • cancer treatment-colon cancer(CA marker)
    • fusion protein to signal the expression of perforin (e coli as NKC)
  • streptococcus vaccine
  • p-falciparum gene expression stabilization ; Malaria
  • intestinal vaccine delivery
  • bac to target the larvae; Malaria
  • To separate Tamoxifen (possibly a chiral drug) by uptake the drugs into modified E Coli and bind it to the receptor inside the bacteria.


Biosensor

  • biosensor that sense the present of allergen and release drugs to prevent allergenic response
  • Mimic allergy response-to determine allergen?
  •  fingerprint detection
  •  Can cells response to magnetic fields?
    • Bird GPS ??
    • magnetic field biosensor
  •  biosensor to detect cancer


Environmental

  • E coli to detect toxins in food and flu strain in animals.
  • Biomask
    •  For absorption
  • create a water purifying system that recognize and trap toxic
    • to uptake salt and others- sea water purification
  • bacteria producing water for the use of photosynthesis so that plants can grow well in dry area
    • is it possible to construct water using certain metabolism pathway?


Signalling

  • Multi-color display according to inputs
    • to improve signal inputs
  • DNA methylation as memory storage
  • suffocate the cells
  • baccine
  • To construct guiding E Coli that guide pathogenic bacteria to a region of toxin/UV light.


Application

  • bacterial barometer
  • fill up crack
  • dust repel
  • microscopic spring-using spirobac
  • To construct a Sound sensing bacteria


Modeling

  • modeling the trend of evolution of flu viruses


Bioproduction

  • Methanol in E-coli





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