Team:PKU Beijing/Project

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==='''Idea'''===
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==='''Project Abstract'''===
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We are engineering our E. coli cells to process the correlation information of two enviornmental signal, similar to the process of conditioning in higher orgamisms. We have constructed and tested a series of AND gates which can sense the two signals: the conditioned and unconditioned stimuli. With the presence of both signals, the AND gate outputs a repressor protein and then changes the state of the bistable switch, which acts as a memory module. In this way, our E. coli cells can convert the information about the concurrence of the two signals into its memory. After the memory module is switched and given the "conditioned stimulus", the E. coli cells will pass the information to the reporter module and thus exhibit the "conditioned response."
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:  Back to the beginning of 20th century, Ivan Pavlov brought up the concept "conditioned reflex". The famous work not only earned him the 1904 Nobel Prize in Physiology and Medicine, but also a milestone for the research of learning and cognition. Here in PKU iGEM2009 Team, we built a learning system in E.coli, and we believe it can reflect the mechanism of conditioned reflex. <html>
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Latest revision as of 07:29, 15 October 2009
 

Idea

iCEM logo

The Idea to make a E.coli that can memorize the correlationship between two signals like classical Conditioning is proposed by Longwen Huang. Huang is an undergraduate from Yuanpei College, Peking University

Project Abstract

We are engineering our E. coli cells to process the correlation information of two enviornmental signal, similar to the process of conditioning in higher orgamisms. We have constructed and tested a series of AND gates which can sense the two signals: the conditioned and unconditioned stimuli. With the presence of both signals, the AND gate outputs a repressor protein and then changes the state of the bistable switch, which acts as a memory module. In this way, our E. coli cells can convert the information about the concurrence of the two signals into its memory. After the memory module is switched and given the "conditioned stimulus", the E. coli cells will pass the information to the reporter module and thus exhibit the "conditioned response."



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