Team:PKU Beijing/Team

From 2009.igem.org

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{{:Team:PKU_Beijing/Template:Header}}
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<meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
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<title>iGEM09 PKU_Beijing</title>
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<!-- InstanceBeginEditable name="head" --><!-- InstanceEndEditable -->
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{|align="justify"
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<body>
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|You can write a background of your team here. Give us a background of your team, the members, etc. Or tell us more about something of your choosing.
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<table width="955" border="0" cellpadding="0" cellspacing="0" bgcolor="#0E7AD3">
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    <td colspan="3" bgcolor="#0E7AD3"><img src="https://static.igem.org/mediawiki/2009/9/9f/PKU_Title_Blue.png" width="955" height="250" border="0" usemap="#Title" /></td>
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  </tr>
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''Tell us more about your project. Give us background.  Use this is the abstract of your project. Be descriptive but concise (1-2 paragraphs)''
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|[[Image:Team.png|right|frame|Your team picture]]
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    <td width="50" height="20" bgcolor="#0E7AD3">&nbsp;</td>
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|-
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|align="center"|[[Team:PKU_Beijing | Team Example 2]]
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  <tr>
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    <td width="50" height="40" bgcolor="#0E7AD3">&nbsp;</td>
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    <td bgcolor="#0E7AD3" class="style6"><!-- InstanceBeginEditable name="PageSec" --><img src="https://static.igem.org/mediawiki/2009/2/21/PKU_Welcome_to_Wiki.png" width="250" height="40" /><!-- InstanceEndEditable --></td>
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      <p class="style7">Project Summary</p>
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      <p><strong>A Genetic Circuit for Directed Evolution <em>in vivo</em> </strong></p>
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      <p>Directed evolution is a powerful tool for answering scientific questions or  constructing novel biological systems. Here we present a simple genetic circuit  for in vivo directed evolution which comprises minimal elements for random  mutation and artificial selection. We engineer yeast to generate the DNA mutator  hAID, an essential protein in adaptive immunity, and target it specifically to a  gene of interest. The target gene will be mutated and consequently promptly  evolves. By linking the expression of hAID repressor LacI and favorite gene  functionality, the mutation rate inversely correlates between the functionality  of the desired gene and hAID. This circuit may be adopted for in vivo evolution  in eukaryotic system on genetically encoded targets. It has a variety of   potential applications in academic and industrial contexts, theoretically most  inter-molecular interaction that involves proteins and RNAs. Learn More...</p>
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      <p><span class="style7">Peking University</span><br />
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      </p>
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      <p>Peking University is a comprehensive and National key university. The campus,  known as &quot;Yan Yuan&quot;-- the gardens of Yan, is situated at the northeast of the  Haidian District at the western suburbs of Beijing. It stands near the Yuan Ming  Gardens and the Summer Palace. </p>
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      <p>The university has made an effective combination of the research on important  scientific issues with the training of personnel with high level specialized  knowledge and professional skill as demanded by the country's socialist  modernization. It strives not only for the simultaneous improvements in teaching  and research work, but also for the promotion of interaction and mutual  promotion among various subjects. </p>
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      <p>Peking University has become a center for teaching and research and a  university of the new type, consisting of diverse branches of learning such as  pure and applied sciences, social sciences and the humanities, and sciences of  management and education. Its aim is to rank among the world's best universities  at the beginning of the next century. Learn More... </p>
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      <p class="style7">Road to Jamboree</p>
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      <p class="style7">Acknowledgement</p>
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    <!-- InstanceEndEditable -->
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      <p class="style7"><br />
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<p>&nbsp;</p>
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<map name="Title" id="Title">
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== '''Who we are''' ==
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{|border = "0"
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<area shape="rect" coords="768,203,810,224" href="https://2009.igem.org/Team:PKU_Beijing/Parts" alt="Parts" />
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|-
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<area shape="rect" coords="666,203,743,224" href="https://2009.igem.org/Team:PKU_Beijing/Modeling" alt="The Model" />
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<area shape="rect" coords="461,202,534,225" href="https://2009.igem.org/Team:PKU_Beijing/Team" alt="The Team" />
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<area shape="rect" coords="388,202,436,225" href="https://2009.igem.org/Team:PKU_Beijing" alt="Home" />
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'''Advisors:'''
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*''' Advisor 1''':    Mentor for all
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*'''Advisor 2''':      Our favorite
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*'''Grad Student 1''':    Our leader 
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'''Undergrads:'''
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*'''Student 1''':    Min Lin
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*'''Student 2''':    Rencheng Gao
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*'''Student 3''':    Longwen Huang
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*'''Student 4''':    Hansi Liu
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*'''Student 5''':    Shan Shen
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*'''Student 6''':    Hao Wang
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*'''Student 7''':    Di Wu
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*'''Student 8''':    Shuke Wu
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*'''Student 9''':    Guosheng Zhang
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*'''Student 10''':  Haoqian Zhang
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*'''Student 11''':  Chengzhe Tian
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<gallery>
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Image:Team_Member_Min_Lin.jpg|[[Team:PKU_Beijing/Team/Min_Lin|'''Min Lin''']]
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Image:Team_Member_Rencheng_Gao.JPG|[[Team:PKU_Beijing/Team/Rencheng_Gao|'''Rencheng Gao''']]
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Image:Team_member_Longwen_Huang.png|[[Team:PKU_Beijing/Team/Longwen_Huang|'''Longwen Huang''']]
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Image:Team_Member_Hansi_Liu.jpg|[[Team:PKU_Beijing/Team/Hansi_Liu|'''Hansi Liu''']]
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Image:Team_Member_Shan_Shen.JPG|[[Team:PKU_Beijing/Team/Shan_Shen|'''Shan Shen''']]
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Image:Team_member_Hao_Wang.png|[[Team:PKU_Beijing/Team/Hao_Wang|'''Hao Wang''']]
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Image:Team_Member_Di_Wu.jpg|[[Team:PKU_Beijing/Team/Di_Wu|'''Di Wu''']]
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Image:Team_Member_Shuke_Wu.jpg|[[Team:PKU_Beijing/Team/Shuke_Wu|'''Shuke Wu''']]
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Image:Team_Member_Guosheng_Zhang.jpg|[[Team:PKU_Beijing/Team/Guosheng_Zhang|'''Guosheng Zhang''']]
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Image:Team_Member_Haoqian_Zhang.jpg|[[Team:PKU_Beijing/Team/Haoqian_Zhang|'''Haoqian Zhang''']]
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Image:Team_member_Chengzhe_Tian.png|[[Team:PKU_Beijing/Team/Chengzhe_Tian|'''Chengzhe Tian''']]
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</gallery>
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|}
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== '''What we did''' ==
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(Provide proper attribution for all work)
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== '''Where we're from''' ==
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Revision as of 19:47, 23 June 2009

<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"> iGEM09 PKU_Beijing

 

 

  
   
 

 
 

Project Summary

A Genetic Circuit for Directed Evolution in vivo

Directed evolution is a powerful tool for answering scientific questions or constructing novel biological systems. Here we present a simple genetic circuit for in vivo directed evolution which comprises minimal elements for random mutation and artificial selection. We engineer yeast to generate the DNA mutator hAID, an essential protein in adaptive immunity, and target it specifically to a gene of interest. The target gene will be mutated and consequently promptly evolves. By linking the expression of hAID repressor LacI and favorite gene functionality, the mutation rate inversely correlates between the functionality of the desired gene and hAID. This circuit may be adopted for in vivo evolution in eukaryotic system on genetically encoded targets. It has a variety of potential applications in academic and industrial contexts, theoretically most inter-molecular interaction that involves proteins and RNAs. Learn More...

Peking University

Peking University is a comprehensive and National key university. The campus, known as "Yan Yuan"-- the gardens of Yan, is situated at the northeast of the Haidian District at the western suburbs of Beijing. It stands near the Yuan Ming Gardens and the Summer Palace.

The university has made an effective combination of the research on important scientific issues with the training of personnel with high level specialized knowledge and professional skill as demanded by the country's socialist modernization. It strives not only for the simultaneous improvements in teaching and research work, but also for the promotion of interaction and mutual promotion among various subjects.

Peking University has become a center for teaching and research and a university of the new type, consisting of diverse branches of learning such as pure and applied sciences, social sciences and the humanities, and sciences of management and education. Its aim is to rank among the world's best universities at the beginning of the next century. Learn More...

Road to Jamboree

Acknowledgement


  

 

Notebook Parts The Model The Project The Team Home

Retrieved from "http://2009.igem.org/Team:PKU_Beijing/Team"