Team:SJTU-BioX-Shanghai

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<div style="font-size:95%;">'''海納百川，有容乃大'''</div>
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<div style="margin-top: .2em; font-size: 200%;">'''[[Wikipedia:关于|维基百科]]'''</div>
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<div style="margin-top: .5em; font-size: 95%;">[[Wikipedia:入门|人人可編輯]]的自由百科全書</div>
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Welcome to the award winning TU Delft 2008 iGEM wiki! On this page information about the project and its progress can be found. The climax of this project was the Jamboree in Boston, which has taken place at the 8th and 9th of November in 2008. Our team was awarded a golden medal and the trophy for the best wiki.
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== The Team ==
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This is the first year the TU Delft participates in the iGEM competition. We are six undergraduate students, four instructors and a lot of advisors, willing to help out and think with us when this is necessary. An overview of the people involved and our competences can be found on the [[Team:TUDelft/Team|team]] page.
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==The Project - Engineering a biothermometer==
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The goal of our project is to construct temperature-sensing bacteria ''Escherichia coli''  that changes color at different temperatures. Such a thermometer can be applied e.g. as a temperature reporter system in large-scale fermentations, or as a temperature-inducible protein production system. The functionality of this thermometer relies on the post-transcriptional regulation of a temperature-sensitive RNA structure: it opens and enables the ribosome to bind, only when the temperature exceeds a certain threshold.
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[[Image:System.png|thumb|200px|right|Black box representation of the biothermometer, with temperature as input and color as output. The system can be split into two subsystems: A temperature sensitive input system and a color producing output system. The temperature sensitive input system works as a switch, switching on the output system at a certain temperature.]]
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We designed new artificial temperature sensitive RNA sequences, and developed protocols, using luciferase as a reporter, to test their functionality. For the colour output, we built upon the existing carotene biosynthesis pathway and converted all new elements to the BioBrick standard. Furthermore, we developed mathematical models describing both the temperature sensitive parts and the colour mevalonate pathway, and estimated parameters using the experimental data. The ethical issues in design and possible implementation of a commercial product are also addressed.  
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If you are interested in this project, we invite you to take a closer look at the website. For a more detailed summary of the project, please read the [[Team:TUDelft/Research_Proposal|research proposal]]. For an overview of the results obtained during the summer, please consult the [[Team:TUDelft/Deliverables|deliverables]] section.
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若您在維基百科受益良多，請考慮[[:wikimedia:资助|資助]]基金會添購[[Wikipedia:服务器|設備]]。<br />
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欲與中文版取得聯繫，請至[news://news.gmane.org/gmane.science.linguistics.wikipedia.chinese 新聞組]或寄送[[Wikipedia:邮件列表|電子郵件]]。<br />
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Revision as of 11:03, 1 July 2009

1.jpg

海納百川，有容乃大
人人可編輯的自由百科全書
已有2,964篇中文條目
■ 歡迎
■ FAQ

Template:Browsebar

File:Featured Article Star.svg 特色條目

Template:Feature

File:Newspaper Cover.svg 新闻动态

Template:Itn

File:Symbol support vote.svg 优良条目

Template:Good

File:Nuvola apps package graphics.png 每日图片

Template:Featurepic

File:Torchlight help icon.svg 你知道吗？

Template:Dyk

File:Nuvola apps date.png 历史上的今天

Template:Otd

File:Gold piece.png 特色内容

Template:FCHome

File:Gnome-globe.svg 季节话题

Template:SeasonHome

File:Nuvola apps bookcase.svg 姊妹-{zh-hans:项目;zh-hant:計畫}-

Template:Wikipediasister

若您在維基百科受益良多，請考慮資助基金會添購設備。
欲與中文版取得聯繫，請至新聞組或寄送電子郵件。
If you do not write Chinese but need to contact zh-wikipedia, you can leave your message here.

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