Team:Stanford/ProjectPage

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1 Abstract
2 Background/Significance
3 Biology behind the mechanism we are going to manipulate (explain retinoic acid, tryyp, beta carotine, etc...
4 symbols and how you assigned them, refer to project using these symbols throughout rest of page)
5 Device 1: Anti-Inflammatory Device
6 Device 2: Anti-Immunosuppressive Device
7 Modeling--short explanation of purpose and significant findings, then link to that page
8 Results
9 Analysis
10 Conclusions

Abstract

Inflammatory bowel disease, a chronic inflammatory disorder that affects the gastrointestinal tract, evolves from a complex mixture of genetic and environmental factors that remain incompletely elucidated. A risk factor that predisposes certain individuals to IBD is the composition of the gut’s commensal microbiota and its contribution to the initiation and prolongation of gastrointestinal inflammation. This occurs by inducing deviant responses from the pro-inflammatory Th17 and suppressive Treg lineages. Our goal is to sense and correct such imbalances in individuals suffering from IBDs by creating an Escherichia coli-based bacterial device that polarizes immune cells to have directed differentiation along either the Th17 or T-regulatory lineage from a single CD4 cell population. Our device will consist of two parts. An anti-inflammatory device that redresses injurious gastrointestinal inflammation by detecting a byproduct of Th17 cell proliferation, nitric oxide, and excreting retinoic acid, a marker that down regulates Th17 populations. Likewise, an anti-immunosuppressive device that regulates T-regulatory populations by detecting an analog of tryptophan, a target substrate of T-regulatory markers, and emits interleukin-6, a cytokine that down regulates T-regulatory cells.

We envision our proposed machine as a novel and directed probiotic therapy that will act at the interface between commensal bacteria and human lymphocytes while integrating cutting-edge immunology with synthetic biology.

You can view our project on a more specific breakdown by viewing the pdf Systems Overview

Background/Significance

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Biology behind the mechanism we are going to manipulate (explain retinoic acid, tryyp, beta carotine, etc...

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symbols and how you assigned them, refer to project using these symbols throughout rest of page)

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Device 1: Anti-Inflammatory Device

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Device 2: Anti-Immunosuppressive Device

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Modeling--short explanation of purpose and significant findings, then link to that page

Results

Analysis

Conclusions

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