Team:TUDelft/Ethics conclusions

From 2009.igem.org

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'''Executive Summary'''
 
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Synthetic biology is becoming the dominant term in describing an innovative multidisciplinary field with both promising scientific benefits and important ethical issues at the same time. The surge of interest in engineering living systems is largely due to a reduction in gene sequencing and synthesis costs as well as the completion of the human genome project and developments in automation techniques.  
Synthetic biology is becoming the dominant term in describing an innovative multidisciplinary field with both promising scientific benefits and important ethical issues at the same time. The surge of interest in engineering living systems is largely due to a reduction in gene sequencing and synthesis costs as well as the completion of the human genome project and developments in automation techniques.  
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Revision as of 23:49, 21 October 2009

Executive Summary and Conclusions


Synthetic biology is becoming the dominant term in describing an innovative multidisciplinary field with both promising scientific benefits and important ethical issues at the same time. The surge of interest in engineering living systems is largely due to a reduction in gene sequencing and synthesis costs as well as the completion of the human genome project and developments in automation techniques.

Although the term has been abundantly used for almost a decade, there is no consensus on a definition for synthetic biology. Different practical approaches to synthetic biology research and engineering emanate from different disciplines, resulting in an almost intangible characterization. An attempt by the European Commission to describe synthetic biology resulted in the following working definition: “Synthetic Biology is the engineering of biological components and systems that do not exist in nature and the re-engineering of existing biological elements; it is determined on the intentional design of artificial biological systems, rather than on the understanding of natural biology”.

The goals in synthetic biology range from creating an open source registry for standardized biological parts (initiated by the Massachusetts Institute of Technology ) to environmental control, development of pharmaceuticals and renewable fuel production. There are two main practical approaches involved in pursuing such goals. The bottom-up approach starts by creating synthetic biological systems out of partially artificial components, whereas the top-down approach reduces existing life forms down into its individual components.

Now that research has enabled to change individual biological components, focus lies on constructing complex networks in single-cell and multi-cellular systems. Recently realized accomplishments include the development of nonnative behaviors such as bi-stability, oscillations, bio-sensing and spatial-pattern formation. Furthermore, as the capabilities of synthetic biology advance, applications within biotechnology, pharmaceutics, environment, information technology and renewable energy will emerge.

The issues concerning synthetic biology are partially acknowledged by the scientific community. Unfortunately different stakeholders usually raise only a limited number of concerns, dependent on personal interest or due to insufficient data or unfamiliarity. The concerns that typically appear in literature include bio-safety, bio-security and intellectual property rights. Topics concerning attitude towards life, reductionism, transparency and public involvement that are relatively hard to address but nonetheless important, do not obtain the attention they deserve. Therefore we have propose different frameworks of the major ethical issues involved in synthetic biology, which can function as a potential reference for regulation and policy making. The different road maps illustrate a rough division of the main ethical issues in synthetic biology, differences between physical and non-physical harms in emerging technologies, ethical considerations from a synthetic biology practitioner's point of view and the connection between evolution, life, reductionism and the bottom-up approach in synthetic biology research.

The undervalued but key ethical issues in synthetic biology are mainly concerning reductionism and the bottom-up approach of creating living systems. Issues concerning safety, security and handling of intellectual property rights should mostly be related to politics not ethics. Although these topics need good regulation, ethics does not play a major part there. Instead there should be more focus on questions concerning life, specifically the reductionist (top-down) approach towards understanding life, and the bottom-up approach towards creating life. The reductionist approach in general, is a method to understand complex systems by understanding its subsystems, in synthetic biology specifically the molecular level is targeted to see how biological systems work. In the bottom-up approach systems are pieced together to give rise to bigger systems, as can be done in biology with genetic engineering principles. What happens if the reductionism approach will eventually show us what life is all about? What happens when humans can create living systems? We cannot foresee if research in synthetic biology will be able to reach those goals but since the scientific community is getting closer en closer to the foundation of living systems, these questions become much more important.

We have evaluated these omitted topics and reflected on them quantitatively by carrying out and analyzing a survey amongst 60 supervisors (and advisors) and 168 students, participating in the 2009 International Genetically Engineered Machine competition. The aim was to raise awareness on these particular subjects. Moreover, the collection of many opinions from this particular scientific community contributes to understanding synthetic biology, to see how ethical issues are perceived and to recognize which concerns should be addressed in regulating synthetic biology.


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