Team:UCSF/Future Applications

From 2009.igem.org

(Difference between revisions)
(VISION: Example of a possible application)
(VISION: Example of a possible application)
Line 7: Line 7:
* these tumors are located in the '''gut and lungs''' and are often '''malignant'''
* these tumors are located in the '''gut and lungs''' and are often '''malignant'''
* they are small and therefor '''hard to find'''
* they are small and therefor '''hard to find'''
-
* they '''secrete high levels of serotonin''' - a neuroactive peptide '''detected by Gi-coupled GPCR'''
+
* they '''secrete high levels of serotonin''' - a neuroactive hormone '''detected by Gi-coupled GPCR'''
Our approach could be used to '''engineer a cellular robot''' that:
Our approach could be used to '''engineer a cellular robot''' that:

Revision as of 00:44, 21 October 2009

VISION: Example of a possible application

In the previous sections we have shown you that we can steer cells to new targets, control their speed and attach a payload. Here we describe our vision of what we could do with these engineered cells in the future.

One target for our cells could be carcinoid tumors:

  • these tumors are located in the gut and lungs and are often malignant
  • they are small and therefor hard to find
  • they secrete high levels of serotonin - a neuroactive hormone detected by Gi-coupled GPCR

Our approach could be used to engineer a cellular robot that:

  • detects serotonin and can chemotax to carcinoid tumors
  • delivers imaging reagents (to aid in surgical removal)

or

  • delivers targeted chemotherapeutic drugs to kill tumor
VISION: We could use our engineered cellular robots to home in on carcinoid tumors to deliver imaging or therapeutic reagents.