Team:UC Davis

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Revision as of 03:28, 1 August 2009

UC Davis_home_project_descriptions

Project and team descriptions:

1 in 133 Americans are suffering from a form of autoimmune disorder called Celiac Disease. Celiac Disease is an condition where the small intestines of an affected individual cannot digest gliadin, a protein present in gluten. If consumed, the body kick starts its immune system response. The effects of the immune response include, but are not limited to abdominal pain and vomiting.

One of our teammate's friends is currently suffering from this illness, which prompted us to look into Celiac Disease as our main focus. What we learned that currently, no cure has been found and the only treatment is a gluton free diet. This treatment is very difficult as an overwhelming majority of food contain gluten and gliadin.

This year the University of California: Davis entered the 2009 iGEM competition a focus on creating a new way to treat Celiac. Our project has been split into two tasks. The first is to produce an inducible secretion system; the second is to construct a biological pH sensor to compartmentalize this secretion system in the stomach. Also, this pH system will act as a kill switch if this system were to ever leave the stomach by inducing cell death via pH change. After weeks of reading numerous articles, we are confident that with the correct parts and timing, our two systems can be built in time to present to the iGEM community.

We have recently moved into the synthesis and assembly stage of our two systems.

Though this is our first year in the competition, we feel that we are moving at a good pace, working out kinks along the way.

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-    <tr>
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+style="font-size: 13.5pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;"><br>
-													  		     <tr>
+<big>Project and team descriptions:</big></span></b><span
+style="font-size: 12pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;"><o:p></o:p></span></p>
-                                                                                               </td>
+<div style="text-align: center;"></div>
-																 </tr></form></table></td>
+<div style="text-align: center;"></div>
+<p class="MsoNormal"
-													<td width="17">&nbsp;</td>
+style="margin-bottom: 0.0001pt; line-height: normal; color: rgb(255, 255, 255); text-align: center;"><b><span
-													</tr>
+style="font-size: 13.5pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;">&nbsp;</span></b><span
-										+114	</table></td>
+style="font-size: 12pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;"><o:p></o:p></span><br>
-    </tr>
+<b><span
-    <tr>
+style="font-size: 13.5pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
-      <td valign="top" colspan="2"><img src="https://static.igem.org/mediawiki/2009/0/0f/UC_Davis_M7.jpg" border="0" width="82" height="32" alt=""><img src="https://static.igem.org/mediawiki/2009/c/c9/UC_Davis_m1.jpg" border="0" width="108" height="32" alt=""><img src="https://static.igem.org/mediawiki/2009/d/df/UC_Davis_M2.jpg" border="0" width="108" height="32" alt=""><img src="https://static.igem.org/mediawiki/2009/6/67/UC_Davis_M3.jpg" border="0" width="108" height="32" alt=""><img src="https://static.igem.org/mediawiki/2009/b/b1/UC_Davis_M4.jpg" border="0" width="108" height="32" alt=""><img src="https://static.igem.org/mediawiki/2009/a/a1/UC_Davis_M5.jpg" border="0" width="111" height="32" alt=""><img src="https://static.igem.org/mediawiki/2009/b/b4/UC_Davis_M6.jpg" border="0" width="155" height="32" </td>
+in 133 Americans are suffering
-    </tr>
+from a form of autoimmune disorder called Celiac Disease. Celiac
+Disease is an
-    <tr>
+condition where the small intestines of an affected individual cannot
-      <td valign="top" width="622"  height="100%" bgcolor="#CCCCCC" ><img src="https://static.igem.org/mediawiki/2009/c/ce/UC_Davis_Banner.png" border="0" width="622" height="98" alt=""><br>
+digest
-        	  <table width="622" border="0" cellpadding="0" cellspacing="0" bgcolor="#CCCCCC"   >
+gliadin, a protein present in gluten. If consumed, the body kick starts
-                   <tr>
+its
-                     <td valign="top"  width="417" ><img src="images/text.jpg" border="0" width="417" height="44" alt="">
+immune system response. The effects of the immune response include, but
-					  <table width="417" border="0" cellpadding="0" cellspacing="0">
+are not
-                         <tr>
+limited to abdominal pain and vomiting.</span></b><span
-                           <td valign="top">&nbsp;&nbsp;&nbsp;</td>
+style="font-size: 12pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;"><o:p></o:p></span></p>
-                           <td valign="top">
+<div style="text-align: center;"></div>
+<p class="MsoNormal"
-						             NOTE TO SELF! ADD TEXT HERE. <br><br>
+style="margin-bottom: 0.0001pt; line-height: normal; color: rgb(255, 255, 255); text-align: center;"><b><span
-							 NOTE TO SELF! ADD TEXT HERE.  <br><br>
+style="font-size: 13.5pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;"><br>
- 							 NOTE TO SELF! ADD TEXT HERE.  <br><br>
+&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; One of our teammate's friends is
+currently suffering from this illness, which
-						    </td>
+prompted us to look into Celiac Disease as our main focus. What we
+learned that currently, no cure has been found and the only treatment
-                           <td valign="top">&nbsp;&nbsp;&nbsp;</td>
+is a gluton free diet.
-                         </tr>
+This treatment is very difficult as an overwhelming majority of food
-                       </table></td>
+contain
-                     <td valign="top" width="9" background="images/v_l_bg.jpg"><img src="images/v_line.jpg" border="0" width="9" height="44" alt=""></td>
+gluten and gliadin.</span></b><span
-                     <td valign="top"><img src="images/news.jpg" border="0" width="196" height="44"
+style="font-size: 12pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;"><o:p></o:p></span></p>
-					 alt=""><table width="196" border="0" cellpadding="0" cellspacing="0">
+<div style="text-align: center;"></div>
-                              <tr>
+<p class="MsoNormal"
-                                <td valign="top">&nbsp;&nbsp;&nbsp;</td>
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-                                <td valign="top" style="font-family:arial;" >
+style="font-size: 13.5pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;">&nbsp;</span></b><span
-								    <b>12&nbsp;Feb&nbsp;2002&nbsp;::&nbsp;</b> UPDATE 1<br>TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT <br><br>
+style="font-size: 12pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;"><o:p></o:p></span></p>
+<div style="text-align: center;"></div>
-								    <b>12&nbsp;Feb&nbsp;2002&nbsp;::&nbsp;</b> UPDATE 2<br>TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT <br><br>
+<p class="MsoNormal"
-								    <b>12&nbsp;Feb&nbsp;2002&nbsp;::&nbsp;</b> UPDATE 3<br>TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT TEXT <br><br>
+style="margin-bottom: 0.0001pt; line-height: normal; color: rgb(255, 255, 255); text-align: center;"><b><span
-								<div align="right"><a href="" style="color: black;text-decoration:none;"><b>More Press&gt;&gt;</a>&nbsp;&nbsp;&nbsp;</b></div><br><br>
+style="font-size: 13.5pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
+This year the University of
-								</td>
+California: Davis entered the 2009 iGEM competition a focus on creating
-                                <td valign="top">&nbsp;&nbsp;&nbsp;</td>
+a new
-                              </tr>
+way to treat Celiac. Our project has been split into two tasks. The
-      	                   </table></td>
+first is to
-                   </tr>
+produce an inducible secretion system; the second is to construct a
-				   <tr><td width="622" height="19" background="images/h_l_bg.jpg" colspan="3">&nbsp;</td></tr>
+biological
-               </table>
+pH sensor to compartmentalize this secretion system in the stomach.
-	  </td>
+Also, this
-      <td background="https://static.igem.org/mediawiki/2009/4/40/UC_Davis_Bg2.jpg" valign="top" width="158" >&nbsp;</td>
+pH system will act as a kill switch if this system were to ever leave
+the
-    </tr>
+stomach by inducing cell death via pH change. After weeks of reading
-    <tr>
+numerous
-      <td valign="top" colspan="2" align="center" height="20"><br><br>
+articles, we are confident that with the correct parts and timing, our
-	  <a class="bot" href="">MENU</a>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
+two
-	  <a class="bot" href="">MENU</a>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
+systems can be built in time to present to the iGEM community.</span></b><span
-	  <a class="bot" href="">MENU</a>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
+style="font-size: 12pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;"><o:p></o:p></span></p>
-	  <a class="bot" href="">MENU</a>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
+<div style="text-align: center;"></div>
+<div style="text-align: center;"></div>
-	  <a class="bot" href="">MENU</a>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
+<p class="MsoNormal"
-	  <a class="bot" href="">MENU</a>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
+style="margin-bottom: 0.0001pt; line-height: normal; color: rgb(255, 255, 255); text-align: center;"><span
-	  <a class="bot" href="">MENU</a>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
+style="font-size: 12pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;"><o:p>&nbsp;</o:p></span><br>
-	  <a class="bot" href="">MENU</a>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
+<b><span
-	  <a class="bot" href="">MENU</a>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
+style="font-size: 13.5pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;">We
+have recently moved into the synthesis
-	  <br>
+and assembly stage of our two systems.</span></b><span
+style="font-size: 12pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;"><o:p></o:p></span></p>
+<div style="text-align: center;"></div>
+<div style="text-align: center;"></div>
-    </tr>
+<p class="MsoNormal"
-</table>
+style="margin-bottom: 5pt; line-height: normal; color: rgb(255, 255, 255); text-align: center;"><span
+style="font-size: 12pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;"><o:p>&nbsp;</o:p></span><b><span
+style="font-size: 13.5pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;">Though
-</td>
+this is our first year in the competition, we feel
-<td width="100%" background="images/bg.gif">&nbsp;</td>
+that we are moving at a good pace, working out kinks along the way.</span></b><span
-</tr>
+style="font-size: 12pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;"><o:p></o:p></span></p>
-</table>
+<div style="text-align: center;"></div>
+<p style="color: rgb(255, 255, 255); text-align: center;"
+class="MsoNormal"><o:p>&nbsp;</o:p></p>
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