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Team:ULB-Brussels/Project/Mathematical
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| + | ==Introduction== | ||
| + | Synthetic biology is a recent development in biology which aims at producing useful material via biological agents. In this context, a biological system can be seen as a complex network composed of different functional parts (\cite{uri}). Mathematical tools allow one to make prediction on the dynamical behaviour of a given bio-system. We aim at studying ft | ||
| + | the system which has been built in the second section of this report. We already know from our experiment that our system is able to produce glue in the presence of IPTG inductor. We now address the following question: what is the influence of the different parameters on the global dynamics (degradation rate, production rate, level of initial quantity for the C$2$P$22$ repressor,...) with and without IPTG. In order to achieve this task, we will consider three different models: the first one shows the basal property we are looking for: a system able to produce glue. The two next models can be seen as two different steps of improvement. The purpose of these models is to improve the experimental control of the glue production. Parameters values result from the literature and previous iGEM team wiki's. We know these remain qualitative and that lab work should be carried out to specify them more precisely. | ||
Revision as of 23:35, 21 October 2009
Introduction
Synthetic biology is a recent development in biology which aims at producing useful material via biological agents. In this context, a biological system can be seen as a complex network composed of different functional parts (\cite{uri}). Mathematical tools allow one to make prediction on the dynamical behaviour of a given bio-system. We aim at studying ft
the system which has been built in the second section of this report. We already know from our experiment that our system is able to produce glue in the presence of IPTG inductor. We now address the following question: what is the influence of the different parameters on the global dynamics (degradation rate, production rate, level of initial quantity for the C$2$P$22$ repressor,...) with and without IPTG. In order to achieve this task, we will consider three different models: the first one shows the basal property we are looking for: a system able to produce glue. The two next models can be seen as two different steps of improvement. The purpose of these models is to improve the experimental control of the glue production. Parameters values result from the literature and previous iGEM team wiki's. We know these remain qualitative and that lab work should be carried out to specify them more precisely.
