Team:Utah State/ETHICS

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USU iGem Untitled Document

ETHICS
Synthetic Biology: Education in an Emerging Field

The iGEM competition is devoted to the advancement of synthetic biology, specifically in standardized parts-based research. It welcomes participants from institutions of higher education from around the world. Just as important as contributing to the understanding of molecular biology based engineering is contributing to a framework which allows applications of this knowledge to be implemented in a manner that serves society. As we address human practices on our wiki we give a brief overview of synthetic biology, list areas in human practice commonly recognized as needing address, pose questions for discussion associated with those areas, and outline two ways the iGEM community can take fundamental actions. These actions involve a broader education of iGEM participants, and the dissemination of knowledge in our educational and public communities.


Synthetic Biology and Human Practices

Synthetic biology has been hailed by some as the next technological revolution. It has been said that standard biological parts “will be for the 21st century what screws and bolts were to the 19th, or transistors and resistors to the 20th (Endy quoted in Parens, Johnston, and Moses, 2009).” Members in the field have visions of using synthetic biology to develop new applications in the areas of environment, health, and industry, as well as learning to understand the fundamental components of life itself. Significant progress has already been made evidenced by the ever increasing size of the registry of parts with applications in the areas listed above. With time other applications will likely arise.

As with any new technology, there exist potential benefits and potential areas of concern. There must be a balance between the desire to bring innovative and beneficial products to market and prevent potential harm to public health and the environment (Rodemeyer, 2009). Following are some of the issues that are commonly indicated as areas that must be addressed.


  • Biosafety: How can research personnel, the environment, and society be protected from intended or accidental exposure to developed products?
  • Biosecurity: What measures should be taken to ensure that products of synthetic biology are not used in a malevolent manner?
  • Property Rights: What is the best way to share information to ensure that the field progresses rapidly, that opportunities to contribute are distributed fairly, and that contributors to the field are fairly compensated? Is it ethical to have a patent on life?
  • Governance: What is the best way to implement policy that governs the field of synthetic biology? Is there a need for outside oversight or is self-governance sufficient? What challenges would arise if governing policy varied from country to country?
  • Mankind and Nature: What roles should humans play in manipulating nature? Who should decide to what extent manipulation of life is acceptable?
  • Public Perception and Involvement: Public involvement often is a deciding factor in funding and regulation. How should synthetic biology disseminate knowledge to the public and hear and address public concerns?

Efforts have been made to foster discussion about these areas and various measures to address them have been suggested (Maurer et al., 2006; Garfinkel et al., 2007). As synthetic biology is still in its youth, actions taken now and continued efforts to address these concerns in the future will enable the field to progress with minimal hindrance. “Procrastination bears a risk. A productive dialogue may become more difficult as synthetic biology evolves and stakeholders become divided in their opinions about benefits and risks (Rejeski, 2009a).” As the iGEM jamboree is the largest gathering related to synthetic biology in the world, we propose that initiative taken here will have a significant impact on the world. The “current and future leaders of the field” are participating in these gatherings (2009.igem.org/About).


iGEM and Education

Establishing governing policy for synthetic biology is complex and difficult to address (Rodemeyer, 2009). Problems can arise from limited jurisdiction of a governing body (Marchant & Pope, 2009) or the expense and cumbersome nature of monitoring activity (Rodemeyer, 2009) among other difficulties. Whatever policy is decided upon, the ultimate difficulty comes in enforcing the policy.

In preparation for the Synthetic Biology 2.0 conference in 2006, Laurie Zoloth addressing “ethics training” stated:

What is needed is a lab culture which is strong enough and decent enough to teach and model impeccably honest moral science citizenship in the as yet small academic field of synthetic biology… Ethics education cannot be done with websites or software—there is a need for individual moral agency, and for this task, serious questions about the complexities of good and evil, difficult moral choices, the nature of the love of country, the nature of obligation to the other and the limits of the search for knowledge, all must be read about and studied with the same seriousness that young scientists give to understanding siRNA or nanobiobarcodes.

As the current and future leaders of the field of synthetic biology participate in these conferences, time before the conference and during the conference should be devoted to establishing appropriate human practices and ensuring that these practices are taught and implemented. The nature of iGEM and its multidisciplinary approach to a successful team is conducive to researching and establishing appropriate human practices. In order to qualify for a gold medal, teams are encouraged to address appropriate human practices as part of their project. Due to the difficult nature of the questions concerning human practices, we propose more could be done by iGEM participants. Possible additional measures include:

    A new track focused solely on researching proper human practices, performing risk assessment, or researching public perception. A portion of the conference set aside to relaying current best practices, or bringing before the community options for current best practices for discussion and acceptance.