Team:Valencia/Simulations

From 2009.igem.org

(Difference between revisions)
Line 7: Line 7:
#footer-box{
#footer-box{
        
        
-
           margin: 10px 0px 0px 143px;
+
           margin: 10px 0px 0px 144px;
         }
         }

Revision as of 23:04, 21 October 2009



Try Your Own Simulations


Here you have a "demo" where you can see our system's response with differents parameters (a further explanation is available below):




Click on the following image to download the application and try your own simulations!



Our Simulations

Before simulating how intracellular calcium concentration changes in time, we have approximated the excitatory post-synaptic potential function (our "input" in neurons) as follows:

Voltage neurons.jpg

Then, taking into account all the factors listed in Our Model (Calcium current through VDCCs, Calcium Buffering and Calcium pumps), the result of simulating free intracellular calcium concentration after the electrical stimulation in neurons is this:


Calcium neurons.jpg


On the other hand, cardiomyocytes have a different response to an electrical stimulus, as now our “input” voltage function is different: unlike neurons, its plasma membrane is held at a high voltage for a few hundred milliseconds.

Voltage muscle.jpg
Calcium muscle.jpg

The numeric values for the simulation parameters are shown in the following table:

Tabla.jpg