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Latest revision as of 00:36, 22 October 2009


Here you have a "demo" where you can see our system's response with differents parameters (a further explanation is available below):

Click on the following image to download the application and try your own simulations!

Our Simulations

Before simulating how intracellular calcium concentration changes in time, we have approximated the excitatory post-synaptic potential function (our "input" in neurons) as follows:

Voltage neurons.jpg

Then, taking into account all the factors listed in Our Model (Calcium current through VDCCs, Calcium Buffering and Calcium pumps), the result of simulating free intracellular calcium concentration after the electrical stimulation in neurons is this:

Calcium neurons.jpg

On the other hand, cardiomyocytes have a different response to an electrical stimulus, as now our “input” voltage function is different: unlike neurons, its plasma membrane is held at a high voltage for a few hundred milliseconds.

Voltage muscle.jpg
Calcium muscle.jpg

The numeric values for the simulation parameters are shown in the following table: