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Team:Virginia/Idea
From 2009.igem.org
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[[Image:Idea.png|200px]] | [[Image:Idea.png|200px]] | ||
| - | + | =Biosequestration= | |
(Intro about biosequestration) | (Intro about biosequestration) | ||
| - | + | =Storage and binding= | |
| - | Surveying evolved strategies for arsenic detoxification in bacteria shows that the most common mechanisms involve the efflux of arsenic ions. | + | Surveying evolved strategies for arsenic detoxification in bacteria shows that the most common mechanisms involve the efflux of arsenic ions. Our goal is to sequester arsenic, therefore to use a microbial chassis we must inhibit its efflux mechanism. However, storage of free arsenic ions in a cell will be toxic. Therefore a successful arsenic sponge needs to also incorporate a binding mechanism that allows the cell to accumulate significant amounts of arsenic. |
''Escherichia coli'' uses the [http://ecoliwiki.net/colipedia/index.php/arsB ArsB] ion transporter | ''Escherichia coli'' uses the [http://ecoliwiki.net/colipedia/index.php/arsB ArsB] ion transporter | ||
Revision as of 16:03, 21 October 2009
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Biosequestration
(Intro about biosequestration)
Storage and binding
Surveying evolved strategies for arsenic detoxification in bacteria shows that the most common mechanisms involve the efflux of arsenic ions. Our goal is to sequester arsenic, therefore to use a microbial chassis we must inhibit its efflux mechanism. However, storage of free arsenic ions in a cell will be toxic. Therefore a successful arsenic sponge needs to also incorporate a binding mechanism that allows the cell to accumulate significant amounts of arsenic.
Escherichia coli uses the ArsB ion transporter
