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Team:Warsaw/Glossary
From 2009.igem.org
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====apoptosis==== | ====apoptosis==== | ||
| - | <div class="glossary_text">Apoptosis is a natural process of programmed cell death. Apoptosis can be induced by many factors and its function is to remove damaged and unnecessary cells from the organism. In our project we want to induce apoptosis of tumor cells, using [https://2009.igem.org/Team:Warsaw/Glossary#p53 p53] or [https://2009.igem.org/Team:Warsaw/Glossary#bax bax] proteins, both involved in control of this process</div> | + | <div class="glossary_text">Apoptosis is a natural process of programmed cell death. Apoptosis can be induced by many factors and its function is to remove damaged and unnecessary cells from the organism. In our project we want to induce apoptosis of tumor cells, using [https://2009.igem.org/Team:Warsaw/Glossary#p53 p53] or [https://2009.igem.org/Team:Warsaw/Glossary#bax bax] proteins, both involved in control of this process </div> |
====bax==== | ====bax==== | ||
| - | <div class="glossary_text">Bcl-2–associated X protein (bax) is a pro-apoptotic protein. Although it's found mainly in the cytosol, upon initiation of [https://2009.igem.org/Team:Warsaw/Glossary#apoptosis apoptosis] it's shifted to organellar membranes. It's believed that bax is responsible for opening special channels in the mitochondrial outer membrane, causing release of pro-apoptotic factors like cytochrome c. | + | <div class="glossary_text">Bcl-2–associated X protein (bax) is a pro-apoptotic protein. Although it's found mainly in the cytosol, upon initiation of [https://2009.igem.org/Team:Warsaw/Glossary#apoptosis apoptosis] it's shifted to organellar membranes. It's believed that bax is responsible for opening special channels in the mitochondrial outer membrane, causing release of pro-apoptotic factors like cytochrome c.</div> |
====cro==== | ====cro==== | ||
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====invasin==== | ====invasin==== | ||
| + | |||
| + | <div class="glossary_text">Invasin is one of proteins crucial for pathogenic features of enteropathogenic bacteria like ''Yersinia'' sp. or ''Salmonella'' sp. Invasin interacts with integrins, receptors occuring on the surface of eukariotic cell membrane, what triggers signalling cascade leading to endocytosis of whole pathogenic bacteria. | ||
| + | </div> | ||
====lacI==== | ====lacI==== | ||
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====listeriolysin==== | ====listeriolysin==== | ||
| - | ====mgtc promoter==== | + | ====mgtc gene promoter==== |
| + | |||
| + | <div class="glossary_text">This is one of the ''Salmonella typhimurium'' PhoP-dependent promoters. MgtC gene is a virulence factor in ''Salmonella typhimurium'' that is required for growth at low-Mg2+ concentrations and intramacrophage survival | ||
| + | </div> | ||
====p53==== | ====p53==== | ||
| - | p53 is a protein well-known for people interested in cancer. p53 is a tumor suppressor and main factor involved in control of cell-cycle, mutated in more than half of tumors. Some data shows that presence of p53 in mitochondria is able to induce [https://2009.igem.org/Team:Warsaw/Glossary#apoptosis apoptosis]. | + | <div class="glossary_text">p53 is a protein well-known for people interested in cancer. p53 is a tumor suppressor and main factor involved in control of cell-cycle, mutated in more than half of tumors. Some data shows that presence of p53 in mitochondria is able to induce [https://2009.igem.org/Team:Warsaw/Glossary#apoptosis apoptosis]. |
| + | </div> | ||
====phoP/PhoQ==== | ====phoP/PhoQ==== | ||
| + | |||
| + | <div class="glossary_text">PhoP/PhoQ is a two-component regulatory system which controls the virulence of ''Salmonella typhimurium''. Under conditions of low pH and/or low metal ions concentration PhoP activates promoters responsible for virulence and sirvival of Salmonella within macrophages, like the [https://2009.igem.org/Team:Warsaw/Glossary#mgtc_gene_promoter promoter of mgtc gene]. Whole system will be used to control bacteria escape from [https://2009.igem.org/Team:Warsaw/Glossary#ensosome endosome] | ||
| + | </div> | ||
====secretion system==== | ====secretion system==== | ||
Revision as of 15:51, 16 August 2009
Glossary
apoptosis
Apoptosis is a natural process of programmed cell death. Apoptosis can be induced by many factors and its function is to remove damaged and unnecessary cells from the organism. In our project we want to induce apoptosis of tumor cells, using p53 or bax proteins, both involved in control of this process
bax
Bcl-2–associated X protein (bax) is a pro-apoptotic protein. Although it's found mainly in the cytosol, upon initiation of apoptosis it's shifted to organellar membranes. It's believed that bax is responsible for opening special channels in the mitochondrial outer membrane, causing release of pro-apoptotic factors like cytochrome c.
cro
cro-box
endosome
invasin
Invasin is one of proteins crucial for pathogenic features of enteropathogenic bacteria like Yersinia sp. or Salmonella sp. Invasin interacts with integrins, receptors occuring on the surface of eukariotic cell membrane, what triggers signalling cascade leading to endocytosis of whole pathogenic bacteria.
lacI
listeriolysin
mgtc gene promoter
This is one of the Salmonella typhimurium PhoP-dependent promoters. MgtC gene is a virulence factor in Salmonella typhimurium that is required for growth at low-Mg2+ concentrations and intramacrophage survival
p53
p53 is a protein well-known for people interested in cancer. p53 is a tumor suppressor and main factor involved in control of cell-cycle, mutated in more than half of tumors. Some data shows that presence of p53 in mitochondria is able to induce apoptosis.
phoP/PhoQ
PhoP/PhoQ is a two-component regulatory system which controls the virulence of Salmonella typhimurium. Under conditions of low pH and/or low metal ions concentration PhoP activates promoters responsible for virulence and sirvival of Salmonella within macrophages, like the promoter of mgtc gene. Whole system will be used to control bacteria escape from endosome
