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Figure:Hand abrasion, 30 minutes after injury.
Coagulation: Any injury results in disruption of blood vessels leading to haemorrhage which is controlled by clot formation which contains fibrin mesh with aggregated platelets embedded in it. Fibrin is the end product of coagulation pathway and besides causing heamostasis it is also the primary component of the provisional tissue matrix seen in the early phases of wound healing. It provides a scaffold for the migration of inflammatory and mesenchymal cells.
Platelet aggregation is a vicious cycle and leads to release of cytokines, which includes PDGF, TGF-a, FGFb, PDEGF. These cytokines influence wound healing directly or indirectly.
The processes of clot formation and platelet aggregation terminate when stimuli for clot formation dissipate.
Lysis of clot starts along with clot formation and is mediated by plasminogen activator, which converts plasminogen to plasmin.
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