Team:DTU Denmark/yeast.html
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Revision as of 14:28, 3 October 2009
Home | The Team | The Project | Parts submitted | Modelling | Notebook |
The redoxilator - Theoretical background - Yeast as a model organism - Practical approach The USER assembly standard - Principle - Proof of concept - Manual - Primer design software |
The project Yeast as a model organism The utilization of improved micro-organisms for industrial processes is a fact for centuries. From the early stages in the preparation of fermented food and beverages until nowadays. Recent advances in biochemistry, engineering and genetic manipulation techniques, led scientist and engineers to improve micro-organisms in order to enhance their metabolic capabilities for biotechnological applications. Along with these improvements, a far more rational and direct approach to strain improvement have been employed, of what we call Metabolic Engineering. What distinguishes Metabolic Engineering from the classical approaches is the application of advanced analytical tools for identification of suited targets for genetic modifications or even the use of mathematical models to perform in silico design of optimized micro-organisms. The consequences of the changes introduced in these engineered strains can then suggest further modifications to improve cellular performance and therefore Metabolic Engineering can be seen as a cyclic process made of continuous iterations between experimental and analytical work. |
Synthetic Biology “Synthetic Biology is an art of engineering new biological systems that don’t exist in nature.” -Paras Chopra & Akhil Kamma In nature, biological molecules work together in complex systems to serve purposes of the cell. In synthetic biology these molecules are used as individual functional units that are combined to form tailored systems exhibiting complex dynamical behaviour. From ‘design specifications’ generated from computational modelling, engineering-based approaches enables the construction of such new specified gene-regulatory networks. The ultimate goal of synthetic biology is to construct systems that gain new functions, and the perspectives of the technology are enormous. It has already been used in several medical projects2 and is predicted to play a major role in biotech-production and environmental aspects. |
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