"
Team:Imperial College London/Stomach
From 2009.igem.org
(Difference between revisions)
JamesField (Talk | contribs) |
JamesField (Talk | contribs) (→Pepsin) |
||
| Line 30: | Line 30: | ||
Stomach = two types of pepsins (these are activated from zymogen precursors at acidic pH). | Stomach = two types of pepsins (these are activated from zymogen precursors at acidic pH). | ||
| + | |||
{{Imperial/09/Division}} | {{Imperial/09/Division}} | ||
| + | |||
| Line 39: | Line 41: | ||
Enteropeptidase | Enteropeptidase | ||
| + | |||
| + | |||
{{Imperial/09/Division}} | {{Imperial/09/Division}} | ||
Revision as of 16:37, 28 September 2009
Human Digestive Proteases:
- Pepsin = stomach
- Trypsin = duodenum
- Chymotrypsin
- Carboxypeptidase
Pepsin
- Released by chief cells in the stomach.
- Expressed as a zymogen pepsinogen.
- Pepsinogen is converted to pepsin by HCl which is released by parietal cells of the stomach.
- Cleaves at the N-terminus after aromatic amino acids such as phenylalanine, tryptophan, and tyrosine.
- Optimum pH of 1.5 to 2. Pepsin denatures when the pH is more than 5.0.
Stomach = two types of pepsins (these are activated from zymogen precursors at acidic pH).
Duodenum = Endopeptidases (trypsin, chymotryopsin, elastase)
Exopeptidases (carboxypeptidases A & B)
Enteropeptidase
Small Intestine = Aminopeptidase N
Dipeptidyl aminopeptidase IV
Aminopeptidase P
Carboxypeptidase P
Angotensin-converting enzyme
Glutamyl aminopeptidase
