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Team:Imperial College London/Opiorphin
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Short chain polypeptides have many applications in the field of biopharmaceuticals. Probems arise int he fact that it is difficult to isolate these short chain peptides without the amino acid methionine as the first amino acid in the chain (due to the nature in which DNA is translated into protein, see [http://en.wikipedia.org/wiki/Translation_(genetics) here] for details). As a result these short chain peptides can be difficult and expensive to synthesise.<br><br> | Short chain polypeptides have many applications in the field of biopharmaceuticals. Probems arise int he fact that it is difficult to isolate these short chain peptides without the amino acid methionine as the first amino acid in the chain (due to the nature in which DNA is translated into protein, see [http://en.wikipedia.org/wiki/Translation_(genetics) here] for details). As a result these short chain peptides can be difficult and expensive to synthesise.<br><br> | ||
Opiorphin is a good example of a short chain peptide that encounters these difficulties, and we have chosen it to showcase the possibilies of peptide delivery by <i>The E.ncapsulator</i>. Opiorphin is a pentapeptide (five amino acid sequence) that is naturally produced within the body, and plays a role in pain relief, and as an anti-depressant. | Opiorphin is a good example of a short chain peptide that encounters these difficulties, and we have chosen it to showcase the possibilies of peptide delivery by <i>The E.ncapsulator</i>. Opiorphin is a pentapeptide (five amino acid sequence) that is naturally produced within the body, and plays a role in pain relief, and as an anti-depressant. | ||
| + | The chemical is a natural painkillers that can relieve pain as well as morphine but without the addictive and psychological side effects of the traditionally used drug. | ||
Revision as of 12:03, 12 October 2009
Opiorphin
Short chain polypeptides have many applications in the field of biopharmaceuticals. Probems arise int he fact that it is difficult to isolate these short chain peptides without the amino acid methionine as the first amino acid in the chain (due to the nature in which DNA is translated into protein, see [http://en.wikipedia.org/wiki/Translation_(genetics) here] for details). As a result these short chain peptides can be difficult and expensive to synthesise.
Opiorphin is a good example of a short chain peptide that encounters these difficulties, and we have chosen it to showcase the possibilies of peptide delivery by The E.ncapsulator. Opiorphin is a pentapeptide (five amino acid sequence) that is naturally produced within the body, and plays a role in pain relief, and as an anti-depressant.
The chemical is a natural painkillers that can relieve pain as well as morphine but without the addictive and psychological side effects of the traditionally used drug.
