iGem Heidelberg Mission 2009: Spybricks
Establishing new standards for iGEM, the Heidelberg 2009 team will be concerned with developing ways for measuring promoters in mammalian cells, a default chassis and a first evaluation of the recently postulated BioBrick beta proposal 2 (Tom Knight).
Considering the importance of controlling gene expression, our team's work will focus on natural and synthetic mammalian promoters. Our vision is to provide the synthetic biology community with a methodical library of such promoters (with different output strength and sensitivity to different regulatory proteins) and a model which can provide guidance for the development of further synthetic promoters. Our efforts will therefore, from the very beginning, equally entail bioinformatics and wet lab work.
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Team
Thirteen students and eleven advisors are working on this four month project. We split up into several subgroups whos focus and results you can follow on the Notebook and Results page. If you want to know more about the subgroups and the people involved, meet us on our Team page and let's get to know each other better at the Jamboree in Boston.
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Project
Mammalian synthetic biology has huge potential, but it is in need of new standards and of systematic construction of comprehensive part libraries. Promoters are the fundamental elements of every synthetic biological system. We have developed and successfully applied two novel, in silico guided methods for the rational construction of synthetic promoters which respond only to predefined transcription factors.
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The Heartbeat Database
As one of the most important approaches to synthezise synthetic promotors we developed a database that predicts the position of conserved promotor binding sequences. We identified conserved sequences ourselves, analyzed the data and coded an easy to use interface that ise available for public use.
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Notebook
What's about documenation? You will find the entire progress of the project and all the important steps on our Notebook page. The Notebook is divided into the individual subgroups.
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Results
Mission Status: accomlished. We generated and characterized sets of constitutive and inducible promotors of different strength using our heartbeat-database prediction software and a new method developed in our lab. We combined a subset of these promotors with our targeted fluorescent protein tag and could thus show... Furthermore we characterized the eukaryotic standart
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Parts
Our team submits a library of well characterized and standardized promotors and sensors for eukaryotic cells. We will also contribute the first eucaryotic standart chassis for iGem featuring standardized genome integration sites.
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Gallery
Spy on our cells or join the Heidelberg Team in the lab with our gallery tour.
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Sponsors
This year we have a lot of distinguished sponsors, which support us and this project.
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Misc
Valencia Gold Medal...
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Our Team
This year 13 students are part of the Heidelberg iGEM Team.
News
28 Aug. 2009, Generous Donation by Klaus Tschira Foundation
The Klaus Tschira Foundation GmbH is a non-profit organization and supports research in informatics, the natural sciences, and mathematics; at the same time it promotes a public understanding in these sciences. With this combination the Klaus Tschira foundation is our ideal partner in this competition.
25 Aug. 2009, LANGE + PFLANZ becomes Gold Sponsor
LANGE + PFLANZ Werbeagentur GmbH (www.lpsp.de) have just declared the sponsorship of our team by designing a team logo, a team shirt, a website, and power-point slides for the Championship Jamboree at MIT. This positions the company - an established marketing and design company which successfully designed the corporate identiy for our Bioquant Institute - right into the sponsorship Gold category. You will find soon the first results on this page!
Sep 2009, iGEM Team Heidelberg wins Gold Medal
The iGEM Team Heidelberg won the Collaboration Gold Medal in the Survey
on Synthetic Biology and by this successfully helped iGEM Team Valencia
by their work on Human Practice!
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